Cross-sectional observational study evaluating the association between odontogenic cystic content and size

•The mean radiographic size of the cysts was 423.70 ± 154.764 mm2.•Cyst size correlated significantly with the Na+: K+ ratio.•Ca+, Cl−, total protein, globulin, albumin, and cholesterols did not affect cyst size. To evaluate and correlate the cystic content and the size of odontogenic cysts. The study included 29 cases of odontogenic cysts reported in the Outpatient Department of Sharad Pawar Dental College. The cystic aspirate was analyzed for levels of sodium, potassium, calcium, chloride, total protein, globulin, albumin, and cholesterol. The sodium/potassium ratio was calculated. Pearson’s correlation coefficient (ρ) was used to correlate the size of the cyst with the sodium/potassium ratio and other cystic contents. P 0.05). The sodium to potassium ratio is positively correlated with the radiographic size of cysts. A thorough analysis of cystic fluid components could provide valuable insights into the potential expansion of odontogenic cysts.