Prognostic Impact of Tumor‐Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients
Objectives/Hypothesis Tumor‐infiltrating lymphocytes (TILs) has been shown to be associated with the prognosis of many tumors, yet few studies have investigated their roles in laryngeal squamous cell carcinoma (LSCC). We aim to investigate the prognostic values of tumor‐infiltrating CD3+/CD4+/CD8+/F...
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| Veröffentlicht in: | The Laryngoscope 2021-04, Vol.131 (4), p.E1249-E1255 |
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| creator | Zhang, Duo Tang, Di Heng, Yu Zhu, Xiao‐Ke Zhou, Liang Tao, Lei Lu, Li‐ming |
| description | Objectives/Hypothesis
Tumor‐infiltrating lymphocytes (TILs) has been shown to be associated with the prognosis of many tumors, yet few studies have investigated their roles in laryngeal squamous cell carcinoma (LSCC). We aim to investigate the prognostic values of tumor‐infiltrating CD3+/CD4+/CD8+/Foxp3+ T‐cells and neutrophils in LSCC patients that received total or partial laryngectomy.
Study Design
Retrospective case series of LSCC patients who underwent total or partial laryngectomy from 2013 to 2014 at Eye, Ear, Nose, and Throat Hospital of Fudan University.
Methods
In our study, 41 tumor tissues from patients with LSCC were retrospectively assessed using immunohistochemistry for CD3+/CD4+/CD8+/Foxp3+ T‐cells and CD66b+ neutrophils. Overall survival (OS) and disease‐free survival (DFS) were recorded using Kaplan–Meier methods.
Results
Generally, patients with high density of TILs (CD3, CD4, CD8) showed improved OS or DFS. Specifically, high density of CD3+ TILs were associated with better OS, yet poorer OS and DFS for CD66b+ neutrophils. Patients with an Immunoscore of 0–1 experienced the worst OS and DFS, compared with Immunoscore 2–4 (P = .0111 for OS, P = .0391 for DFS). In Cox proportional hazards analysis adjusted for N stage and T stage, only stroma CD66b+ neutrophils densities were able to predict OS, with odds ratios of 4.819 (95% confidence interval [CI] 1.149–20.206; P = .032*), and DFS 2.888 (95% CI 1.043–7.997; P = .041*).
Conclusions
The density of TILs and CD66b+ neutrophils may help predict the prognosis of patients with LSCC after surgery.
Level of Evidence
3 Laryngoscope, 131:E1249–E1255, 2021 |
| doi_str_mv | 10.1002/lary.29196 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2454654426</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2499301899</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3576-ecc830faee3a5b6f1a966fd4a9de6db806e44ca4915950c53af8a33f68ad00023</originalsourceid><addsrcrecordid>eNp9kM9qGzEQxkVpiB03lz5AEfRSAutIqz9eHYNpE8NCQuJCe1rGWsldsys50i7FtzxCnjFPEjlOesihl5nD_Oabbz6EPlMypYTk5y2E3TRXVMkPaEwFoxlXSnxE4zRkWSHyXyN0EuOGEDpjghyjEWOUzFQxGyN9E_za-dg3Gi-6Legee4uXQ-fD08Pjwtmm7QP0jVvjctdt_3i9603EjcNluurWBlp8dz9A54eI56Zt8RyCbpzvAN-kPeP6-AkdWWijOX3tE_Tzx_fl_Corry8X84sy00zMZGa0LhixYAwDsZKWgpLS1hxUbWS9Kog0nGvgigoliBYMbAGMWVlATfavTtC3g-42-PvBxL7qmqiTJ3Am2atyLrgUnOcyoV_foRs_BJfcJUopRmiR6gSdHSgdfIzB2Gobmi79XVFS7aOv9tFXL9En-Mur5LDqTP0Pfcs6AfQA_G1as_uPVFVe3P4-iD4DYb2Q1w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2499301899</pqid></control><display><type>article</type><title>Prognostic Impact of Tumor‐Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Zhang, Duo ; Tang, Di ; Heng, Yu ; Zhu, Xiao‐Ke ; Zhou, Liang ; Tao, Lei ; Lu, Li‐ming</creator><creatorcontrib>Zhang, Duo ; Tang, Di ; Heng, Yu ; Zhu, Xiao‐Ke ; Zhou, Liang ; Tao, Lei ; Lu, Li‐ming</creatorcontrib><description>Objectives/Hypothesis
Tumor‐infiltrating lymphocytes (TILs) has been shown to be associated with the prognosis of many tumors, yet few studies have investigated their roles in laryngeal squamous cell carcinoma (LSCC). We aim to investigate the prognostic values of tumor‐infiltrating CD3+/CD4+/CD8+/Foxp3+ T‐cells and neutrophils in LSCC patients that received total or partial laryngectomy.
Study Design
Retrospective case series of LSCC patients who underwent total or partial laryngectomy from 2013 to 2014 at Eye, Ear, Nose, and Throat Hospital of Fudan University.
Methods
In our study, 41 tumor tissues from patients with LSCC were retrospectively assessed using immunohistochemistry for CD3+/CD4+/CD8+/Foxp3+ T‐cells and CD66b+ neutrophils. Overall survival (OS) and disease‐free survival (DFS) were recorded using Kaplan–Meier methods.
Results
Generally, patients with high density of TILs (CD3, CD4, CD8) showed improved OS or DFS. Specifically, high density of CD3+ TILs were associated with better OS, yet poorer OS and DFS for CD66b+ neutrophils. Patients with an Immunoscore of 0–1 experienced the worst OS and DFS, compared with Immunoscore 2–4 (P = .0111 for OS, P = .0391 for DFS). In Cox proportional hazards analysis adjusted for N stage and T stage, only stroma CD66b+ neutrophils densities were able to predict OS, with odds ratios of 4.819 (95% confidence interval [CI] 1.149–20.206; P = .032*), and DFS 2.888 (95% CI 1.043–7.997; P = .041*).
Conclusions
The density of TILs and CD66b+ neutrophils may help predict the prognosis of patients with LSCC after surgery.
Level of Evidence
3 Laryngoscope, 131:E1249–E1255, 2021</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.29196</identifier><identifier>PMID: 33107987</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Aged ; Carcinoma, Squamous Cell - immunology ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; CD3 ; CD66b ; CD8 ; Female ; Humans ; Laryngeal cancer ; Laryngeal Neoplasms - immunology ; Laryngeal Neoplasms - mortality ; Laryngeal Neoplasms - pathology ; Laryngeal Neoplasms - surgery ; laryngeal squamous cell carcinoma ; Laryngectomy ; Laryngoscopy ; Lymphocytes, Tumor-Infiltrating ; Male ; Medical prognosis ; Middle Aged ; Neoplasm Staging ; Neutrophil Infiltration ; Neutrophils ; Prognosis ; Retrospective Studies ; Squamous cell carcinoma ; Survival Rate ; Tumor‐infiltrating lymphocytes</subject><ispartof>The Laryngoscope, 2021-04, Vol.131 (4), p.E1249-E1255</ispartof><rights>2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA)</rights><rights>2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA).</rights><rights>2021 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3576-ecc830faee3a5b6f1a966fd4a9de6db806e44ca4915950c53af8a33f68ad00023</citedby><cites>FETCH-LOGICAL-c3576-ecc830faee3a5b6f1a966fd4a9de6db806e44ca4915950c53af8a33f68ad00023</cites><orcidid>0000-0003-3384-9396</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.29196$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.29196$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33107987$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Duo</creatorcontrib><creatorcontrib>Tang, Di</creatorcontrib><creatorcontrib>Heng, Yu</creatorcontrib><creatorcontrib>Zhu, Xiao‐Ke</creatorcontrib><creatorcontrib>Zhou, Liang</creatorcontrib><creatorcontrib>Tao, Lei</creatorcontrib><creatorcontrib>Lu, Li‐ming</creatorcontrib><title>Prognostic Impact of Tumor‐Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Objectives/Hypothesis
Tumor‐infiltrating lymphocytes (TILs) has been shown to be associated with the prognosis of many tumors, yet few studies have investigated their roles in laryngeal squamous cell carcinoma (LSCC). We aim to investigate the prognostic values of tumor‐infiltrating CD3+/CD4+/CD8+/Foxp3+ T‐cells and neutrophils in LSCC patients that received total or partial laryngectomy.
Study Design
Retrospective case series of LSCC patients who underwent total or partial laryngectomy from 2013 to 2014 at Eye, Ear, Nose, and Throat Hospital of Fudan University.
Methods
In our study, 41 tumor tissues from patients with LSCC were retrospectively assessed using immunohistochemistry for CD3+/CD4+/CD8+/Foxp3+ T‐cells and CD66b+ neutrophils. Overall survival (OS) and disease‐free survival (DFS) were recorded using Kaplan–Meier methods.
Results
Generally, patients with high density of TILs (CD3, CD4, CD8) showed improved OS or DFS. Specifically, high density of CD3+ TILs were associated with better OS, yet poorer OS and DFS for CD66b+ neutrophils. Patients with an Immunoscore of 0–1 experienced the worst OS and DFS, compared with Immunoscore 2–4 (P = .0111 for OS, P = .0391 for DFS). In Cox proportional hazards analysis adjusted for N stage and T stage, only stroma CD66b+ neutrophils densities were able to predict OS, with odds ratios of 4.819 (95% confidence interval [CI] 1.149–20.206; P = .032*), and DFS 2.888 (95% CI 1.043–7.997; P = .041*).
Conclusions
The density of TILs and CD66b+ neutrophils may help predict the prognosis of patients with LSCC after surgery.
Level of Evidence
3 Laryngoscope, 131:E1249–E1255, 2021</description><subject>Aged</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>CD3</subject><subject>CD66b</subject><subject>CD8</subject><subject>Female</subject><subject>Humans</subject><subject>Laryngeal cancer</subject><subject>Laryngeal Neoplasms - immunology</subject><subject>Laryngeal Neoplasms - mortality</subject><subject>Laryngeal Neoplasms - pathology</subject><subject>Laryngeal Neoplasms - surgery</subject><subject>laryngeal squamous cell carcinoma</subject><subject>Laryngectomy</subject><subject>Laryngoscopy</subject><subject>Lymphocytes, Tumor-Infiltrating</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neutrophil Infiltration</subject><subject>Neutrophils</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Squamous cell carcinoma</subject><subject>Survival Rate</subject><subject>Tumor‐infiltrating lymphocytes</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9qGzEQxkVpiB03lz5AEfRSAutIqz9eHYNpE8NCQuJCe1rGWsldsys50i7FtzxCnjFPEjlOesihl5nD_Oabbz6EPlMypYTk5y2E3TRXVMkPaEwFoxlXSnxE4zRkWSHyXyN0EuOGEDpjghyjEWOUzFQxGyN9E_za-dg3Gi-6Legee4uXQ-fD08Pjwtmm7QP0jVvjctdt_3i9603EjcNluurWBlp8dz9A54eI56Zt8RyCbpzvAN-kPeP6-AkdWWijOX3tE_Tzx_fl_Corry8X84sy00zMZGa0LhixYAwDsZKWgpLS1hxUbWS9Kog0nGvgigoliBYMbAGMWVlATfavTtC3g-42-PvBxL7qmqiTJ3Am2atyLrgUnOcyoV_foRs_BJfcJUopRmiR6gSdHSgdfIzB2Gobmi79XVFS7aOv9tFXL9En-Mur5LDqTP0Pfcs6AfQA_G1as_uPVFVe3P4-iD4DYb2Q1w</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Zhang, Duo</creator><creator>Tang, Di</creator><creator>Heng, Yu</creator><creator>Zhu, Xiao‐Ke</creator><creator>Zhou, Liang</creator><creator>Tao, Lei</creator><creator>Lu, Li‐ming</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3384-9396</orcidid></search><sort><creationdate>202104</creationdate><title>Prognostic Impact of Tumor‐Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients</title><author>Zhang, Duo ; Tang, Di ; Heng, Yu ; Zhu, Xiao‐Ke ; Zhou, Liang ; Tao, Lei ; Lu, Li‐ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-ecc830faee3a5b6f1a966fd4a9de6db806e44ca4915950c53af8a33f68ad00023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>CD3</topic><topic>CD66b</topic><topic>CD8</topic><topic>Female</topic><topic>Humans</topic><topic>Laryngeal cancer</topic><topic>Laryngeal Neoplasms - immunology</topic><topic>Laryngeal Neoplasms - mortality</topic><topic>Laryngeal Neoplasms - pathology</topic><topic>Laryngeal Neoplasms - surgery</topic><topic>laryngeal squamous cell carcinoma</topic><topic>Laryngectomy</topic><topic>Laryngoscopy</topic><topic>Lymphocytes, Tumor-Infiltrating</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neutrophil Infiltration</topic><topic>Neutrophils</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Squamous cell carcinoma</topic><topic>Survival Rate</topic><topic>Tumor‐infiltrating lymphocytes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Duo</creatorcontrib><creatorcontrib>Tang, Di</creatorcontrib><creatorcontrib>Heng, Yu</creatorcontrib><creatorcontrib>Zhu, Xiao‐Ke</creatorcontrib><creatorcontrib>Zhou, Liang</creatorcontrib><creatorcontrib>Tao, Lei</creatorcontrib><creatorcontrib>Lu, Li‐ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Duo</au><au>Tang, Di</au><au>Heng, Yu</au><au>Zhu, Xiao‐Ke</au><au>Zhou, Liang</au><au>Tao, Lei</au><au>Lu, Li‐ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Impact of Tumor‐Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2021-04</date><risdate>2021</risdate><volume>131</volume><issue>4</issue><spage>E1249</spage><epage>E1255</epage><pages>E1249-E1255</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
Tumor‐infiltrating lymphocytes (TILs) has been shown to be associated with the prognosis of many tumors, yet few studies have investigated their roles in laryngeal squamous cell carcinoma (LSCC). We aim to investigate the prognostic values of tumor‐infiltrating CD3+/CD4+/CD8+/Foxp3+ T‐cells and neutrophils in LSCC patients that received total or partial laryngectomy.
Study Design
Retrospective case series of LSCC patients who underwent total or partial laryngectomy from 2013 to 2014 at Eye, Ear, Nose, and Throat Hospital of Fudan University.
Methods
In our study, 41 tumor tissues from patients with LSCC were retrospectively assessed using immunohistochemistry for CD3+/CD4+/CD8+/Foxp3+ T‐cells and CD66b+ neutrophils. Overall survival (OS) and disease‐free survival (DFS) were recorded using Kaplan–Meier methods.
Results
Generally, patients with high density of TILs (CD3, CD4, CD8) showed improved OS or DFS. Specifically, high density of CD3+ TILs were associated with better OS, yet poorer OS and DFS for CD66b+ neutrophils. Patients with an Immunoscore of 0–1 experienced the worst OS and DFS, compared with Immunoscore 2–4 (P = .0111 for OS, P = .0391 for DFS). In Cox proportional hazards analysis adjusted for N stage and T stage, only stroma CD66b+ neutrophils densities were able to predict OS, with odds ratios of 4.819 (95% confidence interval [CI] 1.149–20.206; P = .032*), and DFS 2.888 (95% CI 1.043–7.997; P = .041*).
Conclusions
The density of TILs and CD66b+ neutrophils may help predict the prognosis of patients with LSCC after surgery.
Level of Evidence
3 Laryngoscope, 131:E1249–E1255, 2021</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33107987</pmid><doi>10.1002/lary.29196</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3384-9396</orcidid></addata></record> |
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| subjects | Aged Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery CD3 CD66b CD8 Female Humans Laryngeal cancer Laryngeal Neoplasms - immunology Laryngeal Neoplasms - mortality Laryngeal Neoplasms - pathology Laryngeal Neoplasms - surgery laryngeal squamous cell carcinoma Laryngectomy Laryngoscopy Lymphocytes, Tumor-Infiltrating Male Medical prognosis Middle Aged Neoplasm Staging Neutrophil Infiltration Neutrophils Prognosis Retrospective Studies Squamous cell carcinoma Survival Rate Tumor‐infiltrating lymphocytes |
| title | Prognostic Impact of Tumor‐Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients |
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