Prognostic Impact of Tumor‐Infiltrating Lymphocytes in Laryngeal Squamous Cell Carcinoma Patients
Objectives/Hypothesis Tumor‐infiltrating lymphocytes (TILs) has been shown to be associated with the prognosis of many tumors, yet few studies have investigated their roles in laryngeal squamous cell carcinoma (LSCC). We aim to investigate the prognostic values of tumor‐infiltrating CD3+/CD4+/CD8+/F...
Gespeichert in:
Veröffentlicht in: | The Laryngoscope 2021-04, Vol.131 (4), p.E1249-E1255 |
---|---|
Hauptverfasser: | , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Objectives/Hypothesis
Tumor‐infiltrating lymphocytes (TILs) has been shown to be associated with the prognosis of many tumors, yet few studies have investigated their roles in laryngeal squamous cell carcinoma (LSCC). We aim to investigate the prognostic values of tumor‐infiltrating CD3+/CD4+/CD8+/Foxp3+ T‐cells and neutrophils in LSCC patients that received total or partial laryngectomy.
Study Design
Retrospective case series of LSCC patients who underwent total or partial laryngectomy from 2013 to 2014 at Eye, Ear, Nose, and Throat Hospital of Fudan University.
Methods
In our study, 41 tumor tissues from patients with LSCC were retrospectively assessed using immunohistochemistry for CD3+/CD4+/CD8+/Foxp3+ T‐cells and CD66b+ neutrophils. Overall survival (OS) and disease‐free survival (DFS) were recorded using Kaplan–Meier methods.
Results
Generally, patients with high density of TILs (CD3, CD4, CD8) showed improved OS or DFS. Specifically, high density of CD3+ TILs were associated with better OS, yet poorer OS and DFS for CD66b+ neutrophils. Patients with an Immunoscore of 0–1 experienced the worst OS and DFS, compared with Immunoscore 2–4 (P = .0111 for OS, P = .0391 for DFS). In Cox proportional hazards analysis adjusted for N stage and T stage, only stroma CD66b+ neutrophils densities were able to predict OS, with odds ratios of 4.819 (95% confidence interval [CI] 1.149–20.206; P = .032*), and DFS 2.888 (95% CI 1.043–7.997; P = .041*).
Conclusions
The density of TILs and CD66b+ neutrophils may help predict the prognosis of patients with LSCC after surgery.
Level of Evidence
3 Laryngoscope, 131:E1249–E1255, 2021 |
---|---|
ISSN: | 0023-852X 1531-4995 |
DOI: | 10.1002/lary.29196 |