Longitudinal study of breast cancer risk markers

Longitudinal study of breast cancer risk markers

Atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS) are markers for an increased risk of breast cancer, yet outcomes for these diagnoses are not well‐documented. In this study, all breast biopsies performed for radiologic abnormalities over a 10‐year period were reviewed. Patients with AH...

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Veröffentlicht in:The breast journal 2021-01, Vol.27 (1), p.48-51
Hauptverfasser: Zarwan, Corrine, Diamond, Olivia, Lam, Prudence, Ghebremichael, Musie S., Lotz, Margaret, Shen, Abra H., Sharifi, Sheida, Rozhansky, Flora, Gore, Teresa Ann, Pories, Susan E.
Format: Artikel
Sprache:eng
Schlagworte:
Abnormalities
atypical ductal hyperplasia
atypical hyperplasia
atypical lobular hyperplasia
Breast cancer
Correlation analysis
Health risks
Hyperplasia
lobular carcinoma in situ
Longitudinal studies
Markers
Mastectomy
Risk
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Beschreibung
Zusammenfassung:Atypical hyperplasia (AH) and lobular carcinoma in situ (LCIS) are markers for an increased risk of breast cancer, yet outcomes for these diagnoses are not well‐documented. In this study, all breast biopsies performed for radiologic abnormalities over a 10‐year period were reviewed. Patients with AH or LCIS were followed for an additional 10 years to assess subsequent rates of cancer diagnosis. Long‐term follow‐up showed that 25 (7.8%) patients with AH and 5 patients with LCIS (5.7%) developed breast cancer over the follow‐up period, a lower rate of breast cancer development than predicted by risk models.
ISSN:1075-122X
1524-4741
DOI:10.1111/tbj.14097