Genetics of facial telangiectasia in the Rotterdam Study: a genome‐wide association study and candidate gene approach

Genetics of facial telangiectasia in the Rotterdam Study: a genome‐wide association study and candidate gene approach

Background The severity of facial telangiectasia or red veins is associated with many lifestyle factors. However, the genetic predisposition remains unclear. Objectives We performed a genome‐wide association study (GWAS) on facial telangiectasia in the Rotterdam Study (RS) and tested for replication...

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Veröffentlicht in:Journal of the European Academy of Dermatology and Venereology 2021-03, Vol.35 (3), p.749-754
Hauptverfasser: Mekić, S., Wigmann, C., Gunn, D.A., Jacobs, L.C., Kayser, M., Schikowski, T., Nijsten, T., Pardo, L.M.
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Telangiectasis - genetics
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Zusammenfassung:Background The severity of facial telangiectasia or red veins is associated with many lifestyle factors. However, the genetic predisposition remains unclear. Objectives We performed a genome‐wide association study (GWAS) on facial telangiectasia in the Rotterdam Study (RS) and tested for replication in two independent cohorts. Additionally, a candidate gene approach with known pigmentation genes was performed. Methods Facial telangiectasia were extracted from standardized facial photographs (collected from 2010–2013) of 2842 northwestern European participants (median age 66.9, 56.8% female) from the RS. Our GWAS top hits (P‐value
ISSN:0926-9959
1468-3083
DOI:10.1111/jdv.17014