PD‐L1 expression in NSCLC: Role of cell blocks and concordance between samples

PD‐L1 expression in NSCLC: Role of cell blocks and concordance between samples

Background PD‐L1 immunohistochemistry is currently performed in patients with advanced non‐small cell lung carcinoma (NSCLC) to identify responders to immune checkpoint inhibitors. Cell blocks from fine needle aspiration of NSCLC are frequently used for diagnostic purposes. The aims of the study are...

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Veröffentlicht in:Diagnostic cytopathology 2021-02, Vol.49 (2), p.303-310
Hauptverfasser: Ambrosini‐Spaltro, Andrea, Dubini, Alessandra, Pieri, Federica, Ravaglia, Claudia, Delmonte, Angelo, Poletti, Venerino
Format: Artikel
Sprache:eng
Schlagworte:
Biopsy
cell block
concordance
Lung cancer
NSCLC
PD‐L1
sample
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Zusammenfassung:Background PD‐L1 immunohistochemistry is currently performed in patients with advanced non‐small cell lung carcinoma (NSCLC) to identify responders to immune checkpoint inhibitors. Cell blocks from fine needle aspiration of NSCLC are frequently used for diagnostic purposes. The aims of the study are to analyze: (a) the distribution of PD‐L1 in cell blocks, in comparison to biopsies and surgical specimens; (b) the concordance of PD‐L1 in specimens of the same patients. Methods PD‐L1 analyses conducted in NSCLCs were retrieved. Cell blocks were prepared with the self‐clotting method. PD‐L1 was performed with Dako 22C3 on the Ventana BenchMark ULTRA platform. Results were divided by tumor proportion score (TPS) in 3 categories:
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.24646