Experimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6ТNF—/— Mice

Experimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6ТNF—/— Mice

Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF —/— mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2020-10, Vol.169 (6), p.836-839
Hauptverfasser: Karamova, A. E., Semenova, V. G., Verbenko, D. A., Obraztsova, O. A., Vanchugova, Kh. M., Nikonorov, A. A., Deryabin, D. G., Solomka, V. S., Kubanov, A. A.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Leprosy
Life span
Methods
Pathology
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Zusammenfassung:Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF —/— mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF —/— mice.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04991-7