Vitamin D Status Impacts Genital Mucosal Immunity and Markers of HIV-1 Susceptibility in Women

While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels

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Bibliographische Detailangaben
Veröffentlicht in:	Nutrients 2020-10, Vol.12 (10), p.3176
Hauptverfasser:	Anderson, Sharon M, Thurman, Andrea R, Chandra, Neelima, Jackson, Suzanne S, Asin, Susana, Rollenhagen, Christiane, Ghosh, Mimi, Daniels, Jason, Vann, Nikolas C, Clark, Meredith R, Doncel, Gustavo F
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D 2 - blood Adult Antimicrobial agents Calciferol Cell growth Dietary Supplements Disease Susceptibility - immunology Dosage Female Gene expression Genitalia, Female - immunology HIV HIV Infections - immunology HIV-1 - immunology Human immunodeficiency virus Humans Immune system Immunologic Factors Immunoregulation Infections Laboratories Menstruation Middle Aged Mucosal immunity Mucous Membrane - cytology Mucous Membrane - immunology Nutritional Status - physiology Pilot Projects Proteins Quorum sensing Reproductive system Vagina Vitamin D Vitamin D - administration & dosage Vitamin D - metabolism Vitamin D - pharmacology Vitamin D - physiology Vitamin D Deficiency - immunology Vitamin deficiency Young Adult
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Beschreibung
Zusammenfassung:	While vitamin D insufficiency is known to impact a multitude of health outcomes, including HIV-1, little is known about the role of vitamin D-mediated immune regulation in the female reproductive tract (FRT). We performed a pilot clinical study of 20 women with circulating 25(OH)D levels
ISSN:	2072-6643 2072-6643
DOI:	10.3390/nu12103176