$Enhancement of the extra-fine particle fraction of levofloxacin embedded in excipient matrix formulations for dry powder inhaler using response surface methodology$

Enhancement of the extra-fine particle fraction of levofloxacin embedded in excipient matrix formulations for dry powder inhaler using response surface methodology

•A design space was plotted using response surfaces for optimal outcomes.•Most responses of the optimized runs were within the 95% prediction interval.•The extra-fine particle fraction of optimized formulations of LVFX was >5%.•The usefulness of the design space in another drug, rifampicin, was v...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2021-01, Vol.156, p.105600-105600, Article 105600
Hauptverfasser:	Tse, Jun Yee, Kadota, Kazunori, Imakubo, Tetsuya, Uchiyama, Hiromasa, Tozuka, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Dry powder inhaler formulations Extra-fine particle fraction Response surface methodology Spray-drying process parameters
Online-Zugang:	Volltext
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Zusammenfassung:	•A design space was plotted using response surfaces for optimal outcomes.•Most responses of the optimized runs were within the 95% prediction interval.•The extra-fine particle fraction of optimized formulations of LVFX was >5%.•The usefulness of the design space in another drug, rifampicin, was validated. [Display omitted] Extra-fine particle fraction (eFPF, the fraction of particles with aerodynamic size
ISSN:	0928-0987 1879-0720
DOI:	10.1016/j.ejps.2020.105600