Oxidation specific epitopes in asthma: New possibilities for treatment

•Oxidative stress can damage cellular lipids causing the formation of oxidation specific epitopes (OSEs).•OSEs are danger-associated molecular patterns (DAMPs).•OSEs signal cellular damage or apoptosis to the immune system.•OSEs are found in a variety of chronic diseases, including asthma.•Targeting...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The international journal of biochemistry & cell biology 2020-12, Vol.129, p.105864-105864, Article 105864
Hauptverfasser: Pascoe, Christopher D., Vaghasiya, Jignesh, Halayko, Andrew J.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 105864
container_issue
container_start_page 105864
container_title The international journal of biochemistry & cell biology
container_volume 129
creator Pascoe, Christopher D.
Vaghasiya, Jignesh
Halayko, Andrew J.
description •Oxidative stress can damage cellular lipids causing the formation of oxidation specific epitopes (OSEs).•OSEs are danger-associated molecular patterns (DAMPs).•OSEs signal cellular damage or apoptosis to the immune system.•OSEs are found in a variety of chronic diseases, including asthma.•Targeting OSE clearance in asthma may provide a new avenue of treatment. Oxidative stress is an important feature of asthma pathophysiology that is not currently targeted by any of our frontline treatments. Reactive oxygen species, generated during times of heightened oxidative stress, can damage cellular lipids causing the production of oxidation specific epitopes (OSE). OSEs are elevated in chronic inflammatory diseases and promoting their clearance by the body, through pattern recognition receptors and IgM antibodies, prevents and resolves inflammation and tissue damage in animal models. Current research on OSEs in asthma is limited. Although they are present in the lungs of people with asthma during periods of exacerbation or allergen exposure, we do not know if they are linked with disease pathobiology. This article reviews our current understanding of OSEs in asthma and explores whether targeting OSE clearance mechanisms may be a novel therapeutic intervention for asthma.
doi_str_mv 10.1016/j.biocel.2020.105864
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2452099802</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1357272520301813</els_id><sourcerecordid>2452099802</sourcerecordid><originalsourceid>FETCH-LOGICAL-c362t-72cfdf6b645b908f8be82976f87b6a60d1bd44c05c415616a10ed7b64e68582b3</originalsourceid><addsrcrecordid>eNp9kE1PHDEMhqOqiAXKP0Bojlxmm2QmH8MBqVqxgIS6l_YcJRmP6tXOB0kW6L8nq9ly7MmW_dqv_RByxeiSUSa_b5cORw-7Jaf8UBJa1l_IGdNKl0Ir8TXnlVAlV1wsyHmMW0opE7w6JYuqorJRWp2R9eYdW5twHIo4gccOfQETpnGCWOBQ2Jj-9Pa2-AlvxTTGiA53mDA3uzEUKYBNPQzpGznp7C7C5TFekN_r-1-rx_J58_C0-vFc-kryVCruu7aTTtbCNVR32oHmjZKdVk5aSVvm2rr2VPiaCcmkZRTa3KpBaqG5qy7Izbx3CuPLHmIyPcYMYWcHGPfR8Fpw2jSa8iytZ6kP-e4AnZkC9jb8NYyaA0GzNTNBcyBoZoJ57ProsHc9tJ9D_5Blwd0sgPznK0Iw0SMMHloM4JNpR_y_wweX0INp</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2452099802</pqid></control><display><type>article</type><title>Oxidation specific epitopes in asthma: New possibilities for treatment</title><source>Elsevier ScienceDirect Journals</source><creator>Pascoe, Christopher D. ; Vaghasiya, Jignesh ; Halayko, Andrew J.</creator><creatorcontrib>Pascoe, Christopher D. ; Vaghasiya, Jignesh ; Halayko, Andrew J.</creatorcontrib><description>•Oxidative stress can damage cellular lipids causing the formation of oxidation specific epitopes (OSEs).•OSEs are danger-associated molecular patterns (DAMPs).•OSEs signal cellular damage or apoptosis to the immune system.•OSEs are found in a variety of chronic diseases, including asthma.•Targeting OSE clearance in asthma may provide a new avenue of treatment. Oxidative stress is an important feature of asthma pathophysiology that is not currently targeted by any of our frontline treatments. Reactive oxygen species, generated during times of heightened oxidative stress, can damage cellular lipids causing the production of oxidation specific epitopes (OSE). OSEs are elevated in chronic inflammatory diseases and promoting their clearance by the body, through pattern recognition receptors and IgM antibodies, prevents and resolves inflammation and tissue damage in animal models. Current research on OSEs in asthma is limited. Although they are present in the lungs of people with asthma during periods of exacerbation or allergen exposure, we do not know if they are linked with disease pathobiology. This article reviews our current understanding of OSEs in asthma and explores whether targeting OSE clearance mechanisms may be a novel therapeutic intervention for asthma.</description><identifier>ISSN: 1357-2725</identifier><identifier>EISSN: 1878-5875</identifier><identifier>DOI: 10.1016/j.biocel.2020.105864</identifier><identifier>PMID: 33069787</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Asthma ; Oxidation specific epitopes ; Oxidative stress ; Oxidized phospholipids ; Reactive oxygen species</subject><ispartof>The international journal of biochemistry &amp; cell biology, 2020-12, Vol.129, p.105864-105864, Article 105864</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-72cfdf6b645b908f8be82976f87b6a60d1bd44c05c415616a10ed7b64e68582b3</citedby><cites>FETCH-LOGICAL-c362t-72cfdf6b645b908f8be82976f87b6a60d1bd44c05c415616a10ed7b64e68582b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1357272520301813$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33069787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pascoe, Christopher D.</creatorcontrib><creatorcontrib>Vaghasiya, Jignesh</creatorcontrib><creatorcontrib>Halayko, Andrew J.</creatorcontrib><title>Oxidation specific epitopes in asthma: New possibilities for treatment</title><title>The international journal of biochemistry &amp; cell biology</title><addtitle>Int J Biochem Cell Biol</addtitle><description>•Oxidative stress can damage cellular lipids causing the formation of oxidation specific epitopes (OSEs).•OSEs are danger-associated molecular patterns (DAMPs).•OSEs signal cellular damage or apoptosis to the immune system.•OSEs are found in a variety of chronic diseases, including asthma.•Targeting OSE clearance in asthma may provide a new avenue of treatment. Oxidative stress is an important feature of asthma pathophysiology that is not currently targeted by any of our frontline treatments. Reactive oxygen species, generated during times of heightened oxidative stress, can damage cellular lipids causing the production of oxidation specific epitopes (OSE). OSEs are elevated in chronic inflammatory diseases and promoting their clearance by the body, through pattern recognition receptors and IgM antibodies, prevents and resolves inflammation and tissue damage in animal models. Current research on OSEs in asthma is limited. Although they are present in the lungs of people with asthma during periods of exacerbation or allergen exposure, we do not know if they are linked with disease pathobiology. This article reviews our current understanding of OSEs in asthma and explores whether targeting OSE clearance mechanisms may be a novel therapeutic intervention for asthma.</description><subject>Asthma</subject><subject>Oxidation specific epitopes</subject><subject>Oxidative stress</subject><subject>Oxidized phospholipids</subject><subject>Reactive oxygen species</subject><issn>1357-2725</issn><issn>1878-5875</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kE1PHDEMhqOqiAXKP0Bojlxmm2QmH8MBqVqxgIS6l_YcJRmP6tXOB0kW6L8nq9ly7MmW_dqv_RByxeiSUSa_b5cORw-7Jaf8UBJa1l_IGdNKl0Ir8TXnlVAlV1wsyHmMW0opE7w6JYuqorJRWp2R9eYdW5twHIo4gccOfQETpnGCWOBQ2Jj-9Pa2-AlvxTTGiA53mDA3uzEUKYBNPQzpGznp7C7C5TFekN_r-1-rx_J58_C0-vFc-kryVCruu7aTTtbCNVR32oHmjZKdVk5aSVvm2rr2VPiaCcmkZRTa3KpBaqG5qy7Izbx3CuPLHmIyPcYMYWcHGPfR8Fpw2jSa8iytZ6kP-e4AnZkC9jb8NYyaA0GzNTNBcyBoZoJ57ProsHc9tJ9D_5Blwd0sgPznK0Iw0SMMHloM4JNpR_y_wweX0INp</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Pascoe, Christopher D.</creator><creator>Vaghasiya, Jignesh</creator><creator>Halayko, Andrew J.</creator><general>Elsevier Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202012</creationdate><title>Oxidation specific epitopes in asthma: New possibilities for treatment</title><author>Pascoe, Christopher D. ; Vaghasiya, Jignesh ; Halayko, Andrew J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-72cfdf6b645b908f8be82976f87b6a60d1bd44c05c415616a10ed7b64e68582b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Asthma</topic><topic>Oxidation specific epitopes</topic><topic>Oxidative stress</topic><topic>Oxidized phospholipids</topic><topic>Reactive oxygen species</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pascoe, Christopher D.</creatorcontrib><creatorcontrib>Vaghasiya, Jignesh</creatorcontrib><creatorcontrib>Halayko, Andrew J.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of biochemistry &amp; cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pascoe, Christopher D.</au><au>Vaghasiya, Jignesh</au><au>Halayko, Andrew J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oxidation specific epitopes in asthma: New possibilities for treatment</atitle><jtitle>The international journal of biochemistry &amp; cell biology</jtitle><addtitle>Int J Biochem Cell Biol</addtitle><date>2020-12</date><risdate>2020</risdate><volume>129</volume><spage>105864</spage><epage>105864</epage><pages>105864-105864</pages><artnum>105864</artnum><issn>1357-2725</issn><eissn>1878-5875</eissn><abstract>•Oxidative stress can damage cellular lipids causing the formation of oxidation specific epitopes (OSEs).•OSEs are danger-associated molecular patterns (DAMPs).•OSEs signal cellular damage or apoptosis to the immune system.•OSEs are found in a variety of chronic diseases, including asthma.•Targeting OSE clearance in asthma may provide a new avenue of treatment. Oxidative stress is an important feature of asthma pathophysiology that is not currently targeted by any of our frontline treatments. Reactive oxygen species, generated during times of heightened oxidative stress, can damage cellular lipids causing the production of oxidation specific epitopes (OSE). OSEs are elevated in chronic inflammatory diseases and promoting their clearance by the body, through pattern recognition receptors and IgM antibodies, prevents and resolves inflammation and tissue damage in animal models. Current research on OSEs in asthma is limited. Although they are present in the lungs of people with asthma during periods of exacerbation or allergen exposure, we do not know if they are linked with disease pathobiology. This article reviews our current understanding of OSEs in asthma and explores whether targeting OSE clearance mechanisms may be a novel therapeutic intervention for asthma.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>33069787</pmid><doi>10.1016/j.biocel.2020.105864</doi><tpages>1</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1357-2725
ispartof The international journal of biochemistry & cell biology, 2020-12, Vol.129, p.105864-105864, Article 105864
issn 1357-2725
1878-5875
language eng
recordid cdi_proquest_miscellaneous_2452099802
source Elsevier ScienceDirect Journals
subjects Asthma
Oxidation specific epitopes
Oxidative stress
Oxidized phospholipids
Reactive oxygen species
title Oxidation specific epitopes in asthma: New possibilities for treatment
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T09%3A54%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oxidation%20specific%20epitopes%20in%20asthma:%20New%20possibilities%20for%20treatment&rft.jtitle=The%20international%20journal%20of%20biochemistry%20&%20cell%20biology&rft.au=Pascoe,%20Christopher%20D.&rft.date=2020-12&rft.volume=129&rft.spage=105864&rft.epage=105864&rft.pages=105864-105864&rft.artnum=105864&rft.issn=1357-2725&rft.eissn=1878-5875&rft_id=info:doi/10.1016/j.biocel.2020.105864&rft_dat=%3Cproquest_cross%3E2452099802%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2452099802&rft_id=info:pmid/33069787&rft_els_id=S1357272520301813&rfr_iscdi=true