Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer’s Disease

Polymorphism rs11867353 of Tyrosine Kinase Non-Receptor 1 (TNK1) Gene Is a Novel Genetic Marker for Alzheimer’s Disease

Several single-nucleotide polymorphisms (SNPs) and rare variants of non-receptor tyrosine kinase 1 gene (TNK1) have been associated with Alzheimer’s disease (AD). To date, none of the associations have proven to be of practical importance in predicting the risk of AD either because the evidence is n...

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Veröffentlicht in:Molecular neurobiology 2021-03, Vol.58 (3), p.996-1005
Hauptverfasser: Zeman, Tomáš, Balcar, Vladimir J., Cahová, Kamila, Janoutová, Jana, Janout, Vladimír, Lochman, Jan, Šerý, Omar
Format: Artikel
Sprache:eng
Schlagworte:
Alzheimer's disease
Biomedical and Life Sciences
Biomedicine
Body height
Body mass index
Body weight
Cell Biology
Cognitive ability
Gene polymorphism
Genetic markers
Genotype & phenotype
Kinases
Neurobiology
Neurodegenerative diseases
Neurology
Neurosciences
Polymorphism
Protein-tyrosine kinase receptors
Single-nucleotide polymorphism
Statistical analysis
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Zusammenfassung:Several single-nucleotide polymorphisms (SNPs) and rare variants of non-receptor tyrosine kinase 1 gene (TNK1) have been associated with Alzheimer’s disease (AD). To date, none of the associations have proven to be of practical importance in predicting the risk of AD either because the evidence is not conclusive, or the risk alleles occur at very low frequency. In the present study, we are evaluating the associations between rs11867353 polymorphism of TNK1 gene and both AD and mild cognitive impairment (MCI) in a group of 1656 persons. While the association with AD was found to be highly statistically significant ( p  
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-020-02153-4