Reduced Wide Local Excision Margins are Associated with Increased Risk of Relapse and Death from Merkel Cell Carcinoma

Introduction Current recommendations regarding the size of wide local excision (WLE) margins for Merkel cell carcinoma (MCC) are not well established. Methods WLE and pathologic margins were respectively reviewed from 79 patients with stage I or II MCC, who underwent WLE at Washington University in...

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Veröffentlicht in:Annals of surgical oncology 2021-06, Vol.28 (6), p.3312-3319
Hauptverfasser: Andruska, Neal, Mahapatra, Lily, Brenneman, Randall J., Rich, Jason T., Baumann, Brian C., Compton, Leigh, Thorstad, Wade L., Daly, Mackenzie D.
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Sprache:eng
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Zusammenfassung:Introduction Current recommendations regarding the size of wide local excision (WLE) margins for Merkel cell carcinoma (MCC) are not well established. Methods WLE and pathologic margins were respectively reviewed from 79 patients with stage I or II MCC, who underwent WLE at Washington University in St Louis from 2005 to 2019. Outcomes included local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), distant recurrence-free survival (DRFS), disease-free survival (DFS), and disease-specific survival (DSS). Results Thirty-two percent of patients received adjuvant radiotherapy (aRT). At 1 year, DFS was 51.3%, 71.4%, and 87.8% for patients with WLE margins 
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-09145-7