Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures

CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-...

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Veröffentlicht in:	Cancer cell 2020-11, Vol.38 (5), p.621-623
Hauptverfasser:	Dagher, Oula, King, Tiffany R., Wellhausen, Nils, Posey, Avery D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD19 Immunotherapy Immunotherapy, Adoptive Mice Neoplasms - therapy Oncolytic Viruses T-Lymphocytes - immunology
Online-Zugang:	Volltext
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