Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures

Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures

CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-...

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Veröffentlicht in:Cancer cell 2020-11, Vol.38 (5), p.621-623
Hauptverfasser: Dagher, Oula, King, Tiffany R., Wellhausen, Nils, Posey, Avery D.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antigens, CD19
Immunotherapy
Immunotherapy, Adoptive
Mice
Neoplasms - therapy
Oncolytic Viruses
T-Lymphocytes - immunology
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Zusammenfassung:CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models. CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2020.10.003