Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures
CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-...
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| Veröffentlicht in: | Cancer cell 2020-11, Vol.38 (5), p.621-623 |
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| creator | Dagher, Oula King, Tiffany R. Wellhausen, Nils Posey, Avery D. |
| description | CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models.
CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models. |
| doi_str_mv | 10.1016/j.ccell.2020.10.003 |
| format | Article |
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CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models.</description><identifier>ISSN: 1535-6108</identifier><identifier>EISSN: 1878-3686</identifier><identifier>DOI: 10.1016/j.ccell.2020.10.003</identifier><identifier>PMID: 33064993</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antigens, CD19 ; Immunotherapy ; Immunotherapy, Adoptive ; Mice ; Neoplasms - therapy ; Oncolytic Viruses ; T-Lymphocytes - immunology</subject><ispartof>Cancer cell, 2020-11, Vol.38 (5), p.621-623</ispartof><rights>2020</rights><rights>Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c404t-a7a5fa46348589749f38232df81f82444e640d8aa82117b5176148e2cff812a73</citedby><cites>FETCH-LOGICAL-c404t-a7a5fa46348589749f38232df81f82444e640d8aa82117b5176148e2cff812a73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ccell.2020.10.003$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33064993$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dagher, Oula</creatorcontrib><creatorcontrib>King, Tiffany R.</creatorcontrib><creatorcontrib>Wellhausen, Nils</creatorcontrib><creatorcontrib>Posey, Avery D.</creatorcontrib><title>Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures</title><title>Cancer cell</title><addtitle>Cancer Cell</addtitle><description>CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models.
CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models.</description><subject>Animals</subject><subject>Antigens, CD19</subject><subject>Immunotherapy</subject><subject>Immunotherapy, Adoptive</subject><subject>Mice</subject><subject>Neoplasms - therapy</subject><subject>Oncolytic Viruses</subject><subject>T-Lymphocytes - immunology</subject><issn>1535-6108</issn><issn>1878-3686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMoPkZ_gSBZuumYV9tUcDEUXzAo6LgOmfRWM7bNmLSK_97UUZeu7uVwzr2cD6FjSqaU0OxsNTUGmmbKCBuVKSF8C-1TmcuEZzLbjnvK0ySjRO6hgxBWJKZoXuyiPc5JJoqC76N56dql7XRvXYcXL-D1-hPXzuNH19gKL4bW-XCOF_rVds9Y47LRIViDy9kDjok7-MCz6h26fvAQDtFOrZsARz9zgp6uLhflTTK_v74tZ_PECCL6ROc6rbXIuJCpLHJR1Fwyzqpa0loyIQRkglRSa8kozZcpzTMqJDBTRwfTOZ-g083dtXdvA4RetTaMLHQHbgiKiZTKNCex_wTxjdV4F4KHWq29bbX_VJSoEaNaqW-MasQ4ihFjTJ38PBiWLVR_mV9u0XCxMUCs-W7Bq2AsdAYq68H0qnL23wdfN4-B1Q</recordid><startdate>20201109</startdate><enddate>20201109</enddate><creator>Dagher, Oula</creator><creator>King, Tiffany R.</creator><creator>Wellhausen, Nils</creator><creator>Posey, Avery D.</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201109</creationdate><title>Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures</title><author>Dagher, Oula ; King, Tiffany R. ; Wellhausen, Nils ; Posey, Avery D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c404t-a7a5fa46348589749f38232df81f82444e640d8aa82117b5176148e2cff812a73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Antigens, CD19</topic><topic>Immunotherapy</topic><topic>Immunotherapy, Adoptive</topic><topic>Mice</topic><topic>Neoplasms - therapy</topic><topic>Oncolytic Viruses</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dagher, Oula</creatorcontrib><creatorcontrib>King, Tiffany R.</creatorcontrib><creatorcontrib>Wellhausen, Nils</creatorcontrib><creatorcontrib>Posey, Avery D.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dagher, Oula</au><au>King, Tiffany R.</au><au>Wellhausen, Nils</au><au>Posey, Avery D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures</atitle><jtitle>Cancer cell</jtitle><addtitle>Cancer Cell</addtitle><date>2020-11-09</date><risdate>2020</risdate><volume>38</volume><issue>5</issue><spage>621</spage><epage>623</epage><pages>621-623</pages><issn>1535-6108</issn><eissn>1878-3686</eissn><abstract>CD19-specific CAR-T cell therapies are the gold standard of adoptive cellular immunotherapy for hematopoietic malignancies. In Science Translational Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression in solid tumors, which are then eradicated by CD19-specific CAR-T cells in immunodeficient and immunocompetent mouse models.
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| ispartof | Cancer cell, 2020-11, Vol.38 (5), p.621-623 |
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| language | eng |
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| source | MEDLINE; Cell Press Free Archives; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier) |
| subjects | Animals Antigens, CD19 Immunotherapy Immunotherapy, Adoptive Mice Neoplasms - therapy Oncolytic Viruses T-Lymphocytes - immunology |
| title | Combination Therapy for Solid Tumors: Taking a Classic CAR on New Adventures |
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