The combination of pretreatment prognostic nutritional index and neuron‐specific enolase enhances prognosis predicting value of small cell lung cancer

The combination of pretreatment prognostic nutritional index and neuron‐specific enolase enhances prognosis predicting value of small cell lung cancer

Introduction Tumor and immune‐inflammatory biomarkers have been demonstrated to be closely associated with cancer prognosis. Objective The present study aims to assess the prognostic value of pretreatment prognostic nutritional index (PNI), carcinoembryonic antigen (CEA), and neuron‐specific enolase...

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Veröffentlicht in:The clinical respiratory journal 2021-03, Vol.15 (3), p.264-271
Hauptverfasser: Wang, Chunyan, Jin, Shi, Xu, Shanqi, Cao, Shoubo
Format: Artikel
Sprache:eng
Schlagworte:
CEA
Humans
Lung cancer
Lung Neoplasms - therapy
Medical prognosis
NSE
Nutrition Assessment
Phosphopyruvate Hydratase
PNI
Prognosis
Retrospective Studies
SCLC
Small Cell Lung Carcinoma - drug therapy
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Zusammenfassung:Introduction Tumor and immune‐inflammatory biomarkers have been demonstrated to be closely associated with cancer prognosis. Objective The present study aims to assess the prognostic value of pretreatment prognostic nutritional index (PNI), carcinoembryonic antigen (CEA), and neuron‐specific enolase (NSE) in small cell lung cancer (SCLC). Methods A retrospective analysis of 301 SCLC patients treated with platinum‐based chemotherapy was performed. Overall survival (OS) was assessed by Kaplan–Meier and multivariate Cox hazard analyses. Results The median OS for total cases was 15.0 months. On univariate analysis, tumor stage (P 
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.13291