Folic acid and vitamin B12 supplementation in subjects with type 2 diabetes mellitus: A multi-arm randomized controlled clinical trial
•Add-on vitamin B12 improved glycaemic control in patients with type 2 diabetes.•Median HbA1c change was – 1.2 % with vitamin B12 versus 0.3 % with control (p = 0.04).•Vitamin B12 also markedly improved insulin resistance & serum adiponectin (p
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| Veröffentlicht in: | Complementary therapies in medicine 2020-09, Vol.53, p.102526-102526, Article 102526 |
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| container_title | Complementary therapies in medicine |
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| creator | Satapathy, Swayamjeet Bandyopadhyay, Debapriya Patro, Binod Kumar Khan, Shahnawaz Naik, Sanjukta |
| description | •Add-on vitamin B12 improved glycaemic control in patients with type 2 diabetes.•Median HbA1c change was – 1.2 % with vitamin B12 versus 0.3 % with control (p = 0.04).•Vitamin B12 also markedly improved insulin resistance & serum adiponectin (p |
| doi_str_mv | 10.1016/j.ctim.2020.102526 |
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This study was conducted to investigate and compare the effects of add-on folic acid and vitamin B12 supplementation on glycaemic control, insulin resistance and serum lipid profile in subjects with type 2 diabetes mellitus.
This study was a randomized, multi-arm, open-label clinical trial. 80 patients with type 2 diabetes and on stable oral antidiabetics were enrolled and 20 patients each were randomly allocated to one of the four groups – Group A: add-on Folic acid (5 mg/day); Group B: add-on Methylcobalamin (500 mcg/day); Group C: add-on Folic acid (5 mg/day) + Methylcobalamin (500 mcg/day) and Group D: Standard oral anti-diabetic drugs. The patients were followed up after 8 weeks.
HbA1c improved significantly in Groups B and C [median changes from baseline – 1.2 % (– 13 mmol/mol) and – 1.5 % (– 16 mmol/mol) respectively, p values 0.04 and 0.02 respectively] compared to Group D. Groups B and C also showed significant improvements in plasma insulin, insulin resistance and serum adiponectin compared to Group D. Serum homocysteine declined significantly in all three groups with add-on supplementation compared to standard treatment. No improvement in the lipid profile was noted in any of the groups.
Add-on supplementation with vitamin B12 improved glycaemic control and insulin resistance in patients with type 2 diabetes mellitus.</description><identifier>ISSN: 0965-2299</identifier><identifier>EISSN: 1873-6963</identifier><identifier>DOI: 10.1016/j.ctim.2020.102526</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adiponectin ; Antidiabetics ; Biochemistry ; Blood pressure ; Clinical trials ; Cyanocobalamin ; Data collection ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetic neuropathy ; Dietary supplements ; Fasting ; Folic acid ; Glucose ; Homocysteine ; Insulin ; Insulin resistance ; Kinases ; Lipids ; Metabolism ; Patients ; Plasma ; Tumor necrosis factor-TNF ; Type 2 diabetes mellitus ; Vitamin B ; Vitamin B 12 ; Vitamin B12</subject><ispartof>Complementary therapies in medicine, 2020-09, Vol.53, p.102526-102526, Article 102526</ispartof><rights>2020 Elsevier Ltd</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c361t-b0260238ac7f4c9ed0f85f9142fe96ec956a7de51392b0fa4b283e043eba545c3</citedby><cites>FETCH-LOGICAL-c361t-b0260238ac7f4c9ed0f85f9142fe96ec956a7de51392b0fa4b283e043eba545c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2450751702?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids></links><search><creatorcontrib>Satapathy, Swayamjeet</creatorcontrib><creatorcontrib>Bandyopadhyay, Debapriya</creatorcontrib><creatorcontrib>Patro, Binod Kumar</creatorcontrib><creatorcontrib>Khan, Shahnawaz</creatorcontrib><creatorcontrib>Naik, Sanjukta</creatorcontrib><title>Folic acid and vitamin B12 supplementation in subjects with type 2 diabetes mellitus: A multi-arm randomized controlled clinical trial</title><title>Complementary therapies in medicine</title><description>•Add-on vitamin B12 improved glycaemic control in patients with type 2 diabetes.•Median HbA1c change was – 1.2 % with vitamin B12 versus 0.3 % with control (p = 0.04).•Vitamin B12 also markedly improved insulin resistance & serum adiponectin (p < 0.05).•High degree of safety noted for add-on vitamin B12 with no observed adverse effect.
This study was conducted to investigate and compare the effects of add-on folic acid and vitamin B12 supplementation on glycaemic control, insulin resistance and serum lipid profile in subjects with type 2 diabetes mellitus.
This study was a randomized, multi-arm, open-label clinical trial. 80 patients with type 2 diabetes and on stable oral antidiabetics were enrolled and 20 patients each were randomly allocated to one of the four groups – Group A: add-on Folic acid (5 mg/day); Group B: add-on Methylcobalamin (500 mcg/day); Group C: add-on Folic acid (5 mg/day) + Methylcobalamin (500 mcg/day) and Group D: Standard oral anti-diabetic drugs. The patients were followed up after 8 weeks.
HbA1c improved significantly in Groups B and C [median changes from baseline – 1.2 % (– 13 mmol/mol) and – 1.5 % (– 16 mmol/mol) respectively, p values 0.04 and 0.02 respectively] compared to Group D. Groups B and C also showed significant improvements in plasma insulin, insulin resistance and serum adiponectin compared to Group D. Serum homocysteine declined significantly in all three groups with add-on supplementation compared to standard treatment. No improvement in the lipid profile was noted in any of the groups.
Add-on supplementation with vitamin B12 improved glycaemic control and insulin resistance in patients with type 2 diabetes mellitus.</description><subject>Adiponectin</subject><subject>Antidiabetics</subject><subject>Biochemistry</subject><subject>Blood pressure</subject><subject>Clinical trials</subject><subject>Cyanocobalamin</subject><subject>Data collection</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetic neuropathy</subject><subject>Dietary supplements</subject><subject>Fasting</subject><subject>Folic acid</subject><subject>Glucose</subject><subject>Homocysteine</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Kinases</subject><subject>Lipids</subject><subject>Metabolism</subject><subject>Patients</subject><subject>Plasma</subject><subject>Tumor necrosis factor-TNF</subject><subject>Type 2 diabetes mellitus</subject><subject>Vitamin 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acid</topic><topic>Glucose</topic><topic>Homocysteine</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Kinases</topic><topic>Lipids</topic><topic>Metabolism</topic><topic>Patients</topic><topic>Plasma</topic><topic>Tumor necrosis factor-TNF</topic><topic>Type 2 diabetes mellitus</topic><topic>Vitamin B</topic><topic>Vitamin B 12</topic><topic>Vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Satapathy, Swayamjeet</creatorcontrib><creatorcontrib>Bandyopadhyay, Debapriya</creatorcontrib><creatorcontrib>Patro, Binod Kumar</creatorcontrib><creatorcontrib>Khan, Shahnawaz</creatorcontrib><creatorcontrib>Naik, Sanjukta</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical 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medicine</jtitle><date>2020-09</date><risdate>2020</risdate><volume>53</volume><spage>102526</spage><epage>102526</epage><pages>102526-102526</pages><artnum>102526</artnum><issn>0965-2299</issn><eissn>1873-6963</eissn><abstract>•Add-on vitamin B12 improved glycaemic control in patients with type 2 diabetes.•Median HbA1c change was – 1.2 % with vitamin B12 versus 0.3 % with control (p = 0.04).•Vitamin B12 also markedly improved insulin resistance & serum adiponectin (p < 0.05).•High degree of safety noted for add-on vitamin B12 with no observed adverse effect.
This study was conducted to investigate and compare the effects of add-on folic acid and vitamin B12 supplementation on glycaemic control, insulin resistance and serum lipid profile in subjects with type 2 diabetes mellitus.
This study was a randomized, multi-arm, open-label clinical trial. 80 patients with type 2 diabetes and on stable oral antidiabetics were enrolled and 20 patients each were randomly allocated to one of the four groups – Group A: add-on Folic acid (5 mg/day); Group B: add-on Methylcobalamin (500 mcg/day); Group C: add-on Folic acid (5 mg/day) + Methylcobalamin (500 mcg/day) and Group D: Standard oral anti-diabetic drugs. The patients were followed up after 8 weeks.
HbA1c improved significantly in Groups B and C [median changes from baseline – 1.2 % (– 13 mmol/mol) and – 1.5 % (– 16 mmol/mol) respectively, p values 0.04 and 0.02 respectively] compared to Group D. Groups B and C also showed significant improvements in plasma insulin, insulin resistance and serum adiponectin compared to Group D. Serum homocysteine declined significantly in all three groups with add-on supplementation compared to standard treatment. No improvement in the lipid profile was noted in any of the groups.
Add-on supplementation with vitamin B12 improved glycaemic control and insulin resistance in patients with type 2 diabetes mellitus.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.ctim.2020.102526</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adiponectin Antidiabetics Biochemistry Blood pressure Clinical trials Cyanocobalamin Data collection Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetic neuropathy Dietary supplements Fasting Folic acid Glucose Homocysteine Insulin Insulin resistance Kinases Lipids Metabolism Patients Plasma Tumor necrosis factor-TNF Type 2 diabetes mellitus Vitamin B Vitamin B 12 Vitamin B12 |
| title | Folic acid and vitamin B12 supplementation in subjects with type 2 diabetes mellitus: A multi-arm randomized controlled clinical trial |
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