Autophagy in Human Diseases

Autophagy in Human Diseases

Autophagy is a complex process of intracellular degradation of senescent or malfunctioning organelles. Dysregulated autophagy is associated with certain cancers, neurodegenerative diseases, immune dysfunction, and aging. Therapies aimed at regulating autophagy are being developed.

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Bibliographische Detailangaben
Veröffentlicht in:The New England journal of medicine 2020-10, Vol.383 (16), p.1564-1576
Hauptverfasser: Mizushima, Noboru, Levine, Beth
Format: Artikel
Sprache:eng
Schlagworte:
Aging
Autophagy
Cytokines
Endoplasmic reticulum
Enzymes
Infections
Lipids
Mammals
Metabolism
Mitochondria
Mutation
Neurodegeneration
Neurodegenerative diseases
Organelles
Phagocytosis
Physiology
Proteins
Stem cells
Tumorigenesis
Yeast
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Beschreibung
Zusammenfassung:Autophagy is a complex process of intracellular degradation of senescent or malfunctioning organelles. Dysregulated autophagy is associated with certain cancers, neurodegenerative diseases, immune dysfunction, and aging. Therapies aimed at regulating autophagy are being developed.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMra2022774