The weak association between neurofilament levels at multiple sclerosis onset and cognitive performance after 9 years
•We observed only a weak association between early sNfL and cognition at 9 years.•There is an association between higher sNfL levels and verbal memory impairment.•Patients with higher sNfL had a trend for higher risk of memory impairment. Neurofilament light chain level in serum (sNfL) and cerebrosp...
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Veröffentlicht in: | Multiple sclerosis and related disorders 2020-11, Vol.46, p.102534-102534, Article 102534 |
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Zusammenfassung: | •We observed only a weak association between early sNfL and cognition at 9 years.•There is an association between higher sNfL levels and verbal memory impairment.•Patients with higher sNfL had a trend for higher risk of memory impairment.
Neurofilament light chain level in serum (sNfL) and cerebrospinal fluid (CSF-NfL) is a promising biomarker of disease activity in multiple sclerosis (MS). However, predictive value of neurofilaments for development of cognitive decline over long-term follow-up has not been extensively studied.
To investigate the relationship between early neurofilament levels and cognitive performance after 9-years.
We included 58 MS patients from the SET study. sNfL levels were measured at screening, at 1 and 2 years. CSF-NfL were measured in 36 patients at screening. Cognitive performance was assessed by the Brief International Cognitive Assessment for Multiple Sclerosis and the Paced Auditory Serial Addition Test-3 s at baseline, at 1, 2 and 9 years. Association between neurofilament levels and cognition was analyzed using Spearman´s correlation, logistic regression and mixed models.
We did not observe associations among early sNfL levels and cross-sectional or longitudinal cognitive measures, except of a trend for association between higher sNfL levels at screening and lower California Verbal Learning Test-II (CVLT-II) scores at year 1 (rho=-0.31, unadjusted p = 0.028). Higher sNfL level was not associated with increased risk of cognitive decline, except of a trend for greater risk of CVLT-II decrease in patients with higher sNfL levels at 1 year (OR=15.8; 95% CI=1.7–147.0; unadjusted p = 0.015). Similar trends were observed for CSF-NfL.
We found only weak association between sNfL levels at disease onset and evolution of cognitive performance over long-term follow-up. |
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ISSN: | 2211-0348 2211-0356 |
DOI: | 10.1016/j.msard.2020.102534 |