Ocular Surface Squamous Neoplasia: Clinicopathological Analysis and Treatment Outcome of 65 Cases

Objectives: To find out the demography, clinical behaviour and outcome of ocular surface squamous neoplasia (OSSN) in North-west Pakistan. Study Design: Case series. Place and Duration of Study: Department of Ophthalmology, Khyber Teaching Hospital, Peshawar, Pakistan, from March 2011 to December 2017. Methodology: All patients with OSSN consulting this department were registered. A special proforma was designed to document demography, clinical features, management, and follow-up of all cases. At the end of study, the data was analysed using SPSS version 25 and the result compiled. Results: Sixty-five eyes with OSSN were included in the study, in which 40 (61.5%) were males and 25 (38.5%) were females. Mean age of the patients was 61.68 [+ or -] 12.76 years. Twenty-six (40%) patients were farmers and exposed to ultraviolet light for prolong period. Fifty-nine (90.8%) presented with a painless, reddish mass on ocular surface. Average size of neoplasm at presentation was 18.60 [+ or -] 11.30 mm in large dimension. Histopathologically, 23 (35.4%) were carcinoma in situ and 41(63%) invasive squamous cell carcinoma. During the period of follow-up 41 (63.1%) cured, 21 (32.2%) developed recurrence, and 3 (4.6%) patients passed away. Conclusion: _OSSN is common in North-west Pakistan. The presentation is late due to certain socio-economic factors; but overall behaviour of the neoplasm is almost the same as mentioned in other studies from different parts of the world. Key Words: Ocular surface squamous neoplasia (OSSN), conjunctival squamous cell carcinoma, Carcinoma in situ.