Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy through sonocatalytic performance of Curcumin-Poly (Lactic-co-Glycolic Acid) on off-target cells

To assessed the Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy (SACT) by Curcumin-Poly (Lactic-co-Glycolic Acid) nanoparticles (Cur-PLGA-NPs). Cur-PLGA-NPs were synthesized and characterized by Scanning Electron Microscope (SEM), Transmission Elect...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Photodiagnosis and photodynamic therapy 2020-12, Vol.32, p.102022-102022, Article 102022
Hauptverfasser: Pourhajibagher, Maryam, Ahmadi, Hanie, Roshan, Zahra, Bahador, Abbas
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 102022
container_issue
container_start_page 102022
container_title Photodiagnosis and photodynamic therapy
container_volume 32
creator Pourhajibagher, Maryam
Ahmadi, Hanie
Roshan, Zahra
Bahador, Abbas
description To assessed the Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy (SACT) by Curcumin-Poly (Lactic-co-Glycolic Acid) nanoparticles (Cur-PLGA-NPs). Cur-PLGA-NPs were synthesized and characterized by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), and Attenuated Total Reflection Fourier Transform IR (ATR-FTIR) spectroscopy, as well as, determination of in vitro drug release. Following the successful synthesis and characterization of Cur-PLGA-NPs, the cell survival, intracellular ROS production, apoptotic effects, DNA fragmentation, and gene expression levels of pro-inflammatory cytokines were investigated on human gingival fibroblast (HGF) cells as off-target cells through S. mutans bystander-induced bioeffects following SACT (BCSS). No significant cytotoxic and damage caused by the release of ROS from BCSS were observed in HGF cells (P > 0.05). There was no DNA fragmentation and anti-proliferation effects on HGF cells. The expression levels of bFGF, TNF-α, and IL-8 genes were increased after exposure to BCSS to 15.4-, 13.5-, and 8.7-fold, respectively (P < 0.05), while TGF-ß and IL-10 were downregulated to -4.1- and -6.8-fold, respectively (P < 0.05). It could be concluded that there were no bystander bioeffects of targeted sonocatalytic stress on off-target cells.
doi_str_mv 10.1016/j.pdpdt.2020.102022
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2449957521</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1572100020303768</els_id><sourcerecordid>2449957521</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-8788e807969e60917dc5aa4bbbbe5ca2975748dd83472bf9ca2fb38599d39cb43</originalsourceid><addsrcrecordid>eNp9kcGOFCEQhjtG466rT2BiOK4HVrrpHuDgYTPR1WQSTdQzoaGYYUJDC_Safj5fTGZn9SiXn1S-nyrqb5rXLblpSbt5d7yZzWzKTUe6U6VK96S5bDmjuB0Ee1rvA-twSwi5aF7kfCSE9oL0z5sLSgnlPd9cNr-_lQRziTpqvWQ0LUWFjMY1VzWQsAtm0WDQ6CJYC7pkZKP38ZcLe5RjiGYNanIaqVBc1RRHpzzSB5hiOUBS84rKIcVlf3jAtSrKr6UaZkg2pkkFDShatF2SXiYX8NfoV3S9U7pCWEd851cdfTXcamfeohgqbXFRaQ8FafA-v2yeWeUzvHrUq-bHxw_ft5_w7svd5-3tDms6iII54xw4YWIjYENEy4welOrHemDQqhNsYD03htOedaMVtWRHygchDBV67OlVc31-d07x5wK5yMnl0wQqQFyy7PpeiIENXVtRekbrQnJOYOWc3KTSKlsiT-nJo3xIT57Sk-f0quvNY4NlnMD88_yNqwLvzwDUb947SDJrB3WDxqWajTTR_bfBH_qlsoM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2449957521</pqid></control><display><type>article</type><title>Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy through sonocatalytic performance of Curcumin-Poly (Lactic-co-Glycolic Acid) on off-target cells</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Pourhajibagher, Maryam ; Ahmadi, Hanie ; Roshan, Zahra ; Bahador, Abbas</creator><creatorcontrib>Pourhajibagher, Maryam ; Ahmadi, Hanie ; Roshan, Zahra ; Bahador, Abbas</creatorcontrib><description>To assessed the Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy (SACT) by Curcumin-Poly (Lactic-co-Glycolic Acid) nanoparticles (Cur-PLGA-NPs). Cur-PLGA-NPs were synthesized and characterized by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), and Attenuated Total Reflection Fourier Transform IR (ATR-FTIR) spectroscopy, as well as, determination of in vitro drug release. Following the successful synthesis and characterization of Cur-PLGA-NPs, the cell survival, intracellular ROS production, apoptotic effects, DNA fragmentation, and gene expression levels of pro-inflammatory cytokines were investigated on human gingival fibroblast (HGF) cells as off-target cells through S. mutans bystander-induced bioeffects following SACT (BCSS). No significant cytotoxic and damage caused by the release of ROS from BCSS were observed in HGF cells (P &gt; 0.05). There was no DNA fragmentation and anti-proliferation effects on HGF cells. The expression levels of bFGF, TNF-α, and IL-8 genes were increased after exposure to BCSS to 15.4-, 13.5-, and 8.7-fold, respectively (P &lt; 0.05), while TGF-ß and IL-10 were downregulated to -4.1- and -6.8-fold, respectively (P &lt; 0.05). It could be concluded that there were no bystander bioeffects of targeted sonocatalytic stress on off-target cells.</description><identifier>ISSN: 1572-1000</identifier><identifier>EISSN: 1873-1597</identifier><identifier>DOI: 10.1016/j.pdpdt.2020.102022</identifier><identifier>PMID: 33038486</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Bystander effects ; Curcumin - pharmacology ; Glycolates ; Glycols ; Human gingival fibroblast cell ; Humans ; Nanoparticles ; Photochemotherapy - methods ; Photosensitizing Agents ; Polylactic Acid-Polyglycolic Acid Copolymer ; Sonodynamic antimicrobial chemotherapy ; Streptococcus mutans</subject><ispartof>Photodiagnosis and photodynamic therapy, 2020-12, Vol.32, p.102022-102022, Article 102022</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-8788e807969e60917dc5aa4bbbbe5ca2975748dd83472bf9ca2fb38599d39cb43</citedby><cites>FETCH-LOGICAL-c359t-8788e807969e60917dc5aa4bbbbe5ca2975748dd83472bf9ca2fb38599d39cb43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1572100020303768$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33038486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pourhajibagher, Maryam</creatorcontrib><creatorcontrib>Ahmadi, Hanie</creatorcontrib><creatorcontrib>Roshan, Zahra</creatorcontrib><creatorcontrib>Bahador, Abbas</creatorcontrib><title>Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy through sonocatalytic performance of Curcumin-Poly (Lactic-co-Glycolic Acid) on off-target cells</title><title>Photodiagnosis and photodynamic therapy</title><addtitle>Photodiagnosis Photodyn Ther</addtitle><description>To assessed the Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy (SACT) by Curcumin-Poly (Lactic-co-Glycolic Acid) nanoparticles (Cur-PLGA-NPs). Cur-PLGA-NPs were synthesized and characterized by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), and Attenuated Total Reflection Fourier Transform IR (ATR-FTIR) spectroscopy, as well as, determination of in vitro drug release. Following the successful synthesis and characterization of Cur-PLGA-NPs, the cell survival, intracellular ROS production, apoptotic effects, DNA fragmentation, and gene expression levels of pro-inflammatory cytokines were investigated on human gingival fibroblast (HGF) cells as off-target cells through S. mutans bystander-induced bioeffects following SACT (BCSS). No significant cytotoxic and damage caused by the release of ROS from BCSS were observed in HGF cells (P &gt; 0.05). There was no DNA fragmentation and anti-proliferation effects on HGF cells. The expression levels of bFGF, TNF-α, and IL-8 genes were increased after exposure to BCSS to 15.4-, 13.5-, and 8.7-fold, respectively (P &lt; 0.05), while TGF-ß and IL-10 were downregulated to -4.1- and -6.8-fold, respectively (P &lt; 0.05). It could be concluded that there were no bystander bioeffects of targeted sonocatalytic stress on off-target cells.</description><subject>Bystander effects</subject><subject>Curcumin - pharmacology</subject><subject>Glycolates</subject><subject>Glycols</subject><subject>Human gingival fibroblast cell</subject><subject>Humans</subject><subject>Nanoparticles</subject><subject>Photochemotherapy - methods</subject><subject>Photosensitizing Agents</subject><subject>Polylactic Acid-Polyglycolic Acid Copolymer</subject><subject>Sonodynamic antimicrobial chemotherapy</subject><subject>Streptococcus mutans</subject><issn>1572-1000</issn><issn>1873-1597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcGOFCEQhjtG466rT2BiOK4HVrrpHuDgYTPR1WQSTdQzoaGYYUJDC_Safj5fTGZn9SiXn1S-nyrqb5rXLblpSbt5d7yZzWzKTUe6U6VK96S5bDmjuB0Ee1rvA-twSwi5aF7kfCSE9oL0z5sLSgnlPd9cNr-_lQRziTpqvWQ0LUWFjMY1VzWQsAtm0WDQ6CJYC7pkZKP38ZcLe5RjiGYNanIaqVBc1RRHpzzSB5hiOUBS84rKIcVlf3jAtSrKr6UaZkg2pkkFDShatF2SXiYX8NfoV3S9U7pCWEd851cdfTXcamfeohgqbXFRaQ8FafA-v2yeWeUzvHrUq-bHxw_ft5_w7svd5-3tDms6iII54xw4YWIjYENEy4welOrHemDQqhNsYD03htOedaMVtWRHygchDBV67OlVc31-d07x5wK5yMnl0wQqQFyy7PpeiIENXVtRekbrQnJOYOWc3KTSKlsiT-nJo3xIT57Sk-f0quvNY4NlnMD88_yNqwLvzwDUb947SDJrB3WDxqWajTTR_bfBH_qlsoM</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Pourhajibagher, Maryam</creator><creator>Ahmadi, Hanie</creator><creator>Roshan, Zahra</creator><creator>Bahador, Abbas</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202012</creationdate><title>Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy through sonocatalytic performance of Curcumin-Poly (Lactic-co-Glycolic Acid) on off-target cells</title><author>Pourhajibagher, Maryam ; Ahmadi, Hanie ; Roshan, Zahra ; Bahador, Abbas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-8788e807969e60917dc5aa4bbbbe5ca2975748dd83472bf9ca2fb38599d39cb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Bystander effects</topic><topic>Curcumin - pharmacology</topic><topic>Glycolates</topic><topic>Glycols</topic><topic>Human gingival fibroblast cell</topic><topic>Humans</topic><topic>Nanoparticles</topic><topic>Photochemotherapy - methods</topic><topic>Photosensitizing Agents</topic><topic>Polylactic Acid-Polyglycolic Acid Copolymer</topic><topic>Sonodynamic antimicrobial chemotherapy</topic><topic>Streptococcus mutans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pourhajibagher, Maryam</creatorcontrib><creatorcontrib>Ahmadi, Hanie</creatorcontrib><creatorcontrib>Roshan, Zahra</creatorcontrib><creatorcontrib>Bahador, Abbas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Photodiagnosis and photodynamic therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pourhajibagher, Maryam</au><au>Ahmadi, Hanie</au><au>Roshan, Zahra</au><au>Bahador, Abbas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy through sonocatalytic performance of Curcumin-Poly (Lactic-co-Glycolic Acid) on off-target cells</atitle><jtitle>Photodiagnosis and photodynamic therapy</jtitle><addtitle>Photodiagnosis Photodyn Ther</addtitle><date>2020-12</date><risdate>2020</risdate><volume>32</volume><spage>102022</spage><epage>102022</epage><pages>102022-102022</pages><artnum>102022</artnum><issn>1572-1000</issn><eissn>1873-1597</eissn><abstract>To assessed the Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy (SACT) by Curcumin-Poly (Lactic-co-Glycolic Acid) nanoparticles (Cur-PLGA-NPs). Cur-PLGA-NPs were synthesized and characterized by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), and Attenuated Total Reflection Fourier Transform IR (ATR-FTIR) spectroscopy, as well as, determination of in vitro drug release. Following the successful synthesis and characterization of Cur-PLGA-NPs, the cell survival, intracellular ROS production, apoptotic effects, DNA fragmentation, and gene expression levels of pro-inflammatory cytokines were investigated on human gingival fibroblast (HGF) cells as off-target cells through S. mutans bystander-induced bioeffects following SACT (BCSS). No significant cytotoxic and damage caused by the release of ROS from BCSS were observed in HGF cells (P &gt; 0.05). There was no DNA fragmentation and anti-proliferation effects on HGF cells. The expression levels of bFGF, TNF-α, and IL-8 genes were increased after exposure to BCSS to 15.4-, 13.5-, and 8.7-fold, respectively (P &lt; 0.05), while TGF-ß and IL-10 were downregulated to -4.1- and -6.8-fold, respectively (P &lt; 0.05). It could be concluded that there were no bystander bioeffects of targeted sonocatalytic stress on off-target cells.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33038486</pmid><doi>10.1016/j.pdpdt.2020.102022</doi><tpages>1</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1572-1000
ispartof Photodiagnosis and photodynamic therapy, 2020-12, Vol.32, p.102022-102022, Article 102022
issn 1572-1000
1873-1597
language eng
recordid cdi_proquest_miscellaneous_2449957521
source MEDLINE; Elsevier ScienceDirect Journals
subjects Bystander effects
Curcumin - pharmacology
Glycolates
Glycols
Human gingival fibroblast cell
Humans
Nanoparticles
Photochemotherapy - methods
Photosensitizing Agents
Polylactic Acid-Polyglycolic Acid Copolymer
Sonodynamic antimicrobial chemotherapy
Streptococcus mutans
title Streptococcus mutans bystander-induced bioeffects following sonodynamic antimicrobial chemotherapy through sonocatalytic performance of Curcumin-Poly (Lactic-co-Glycolic Acid) on off-target cells
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T20%3A57%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Streptococcus%20mutans%20bystander-induced%20bioeffects%20following%20sonodynamic%20antimicrobial%20chemotherapy%20through%20sonocatalytic%20performance%20of%20Curcumin-Poly%20(Lactic-co-Glycolic%20Acid)%20on%20off-target%20cells&rft.jtitle=Photodiagnosis%20and%20photodynamic%20therapy&rft.au=Pourhajibagher,%20Maryam&rft.date=2020-12&rft.volume=32&rft.spage=102022&rft.epage=102022&rft.pages=102022-102022&rft.artnum=102022&rft.issn=1572-1000&rft.eissn=1873-1597&rft_id=info:doi/10.1016/j.pdpdt.2020.102022&rft_dat=%3Cproquest_cross%3E2449957521%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2449957521&rft_id=info:pmid/33038486&rft_els_id=S1572100020303768&rfr_iscdi=true