An AIE probe for imaging mitochondrial SO2-induced stress and SO2 levels during heat stroke

An AIE probe for imaging mitochondrial SO2-induced stress and SO2 levels during heat stroke

A probe, MITO-TPE, was developed for imaging mitochondrial SO2 with good selectivity, high sensitivity, and a fast response time. Cell imaging indicated that SO2-induced oxidative stress may cause damage to cells through O2·− bursting. MITO-TPE has here been used to image the misregulation of SO2 le...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-11, Vol.56 (86), p.13217-13220
Hauptverfasser: Yang, Xiaopeng, Tang, Jun, Zhang, Di, Han, Xiaojing, Liu, Jianfei, Li, Jinsa, Zhao, Yufen, Ye, Yong
Format: Artikel
Sprache:eng
Schlagworte:
Heat stroke
Heatstroke
Medical imaging
Mitochondria
NMR
Nuclear magnetic resonance
Response time
Selectivity
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Zusammenfassung:A probe, MITO-TPE, was developed for imaging mitochondrial SO2 with good selectivity, high sensitivity, and a fast response time. Cell imaging indicated that SO2-induced oxidative stress may cause damage to cells through O2·− bursting. MITO-TPE has here been used to image the misregulation of SO2 levels in mitochondria during heat stroke for the first time.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc05803c