The potential role of HLA-G in the pathogenesis of HBV infection: Immunosuppressive or immunoprotective?

The non-classical human leukocyte antigens (HLA)-G could be generally considered as a potent tolerogenic molecule, which modulates immune responses. HLA-G due to the immunosuppressive properties may play an important role in the pathogenesis of infections related to the liver. HLA-G may display two...

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Veröffentlicht in:Infection, genetics and evolution genetics and evolution, 2020-11, Vol.85, p.104580-104580, Article 104580
Hauptverfasser: Rashidi, Saadyeh, Farhadi, Leila, Ghasemi, Faezeh, Sheikhesmaeili, Farshad, Mohammadi, Asadollah
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Sprache:eng
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Zusammenfassung:The non-classical human leukocyte antigens (HLA)-G could be generally considered as a potent tolerogenic molecule, which modulates immune responses. HLA-G due to the immunosuppressive properties may play an important role in the pathogenesis of infections related to the liver. HLA-G may display two distinct activities in the pathological conditions so that it could be protective in the autoimmune and inflammatory diseases or could be suppressive of the immune system in the infections or cancers. HLA-G might be used as a novel therapeutic target for liver diseases in the future. Indeed, new therapeutic agents targeting HLA-G expression or antibodies which block HLA-G activity are being developed and tested. However, further consideration of the HLA-G function in liver disease is required. This review aims to summarize the role of HLA-G in the liver of patients with HBV infection. •HLA-G due to the immunosuppressive properties plays an important role in the pathogenesis of infections related to the liver.•HLA-G could be protective in autoimmune and inflammatory diseases or could be suppressive in infections or cancers.•Not only the HLA-G expression but also its ins/del polymorphism could have a role in its inhibitory effect and disease susceptibility.•HLA-G might be used as a novel therapeutic target for liver diseases in the future.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2020.104580