SIS3, a good candidate for the reverse of type 2 diabetes mellitus in mice

TGF‐β signaling plays an extremely important role in the occurrence and development of type 2 diabetes mellitus (T2DM), and the blockade of TGF‐β/Smad3 pathway protests against the high‐fat diet‐induced obesity and diabetes. As a specific small molecule inhibitor of Smad3 protein, the biological activities of compound SIS3 were evaluated by high‐fat diet‐induced T2DM model mice. In vivo results indicated that SIS3 can not only significantly reduce the body weight, fat mass, and fasting blood glucose in high‐fat diet‐induced T2DM model mice, but also improve insulin sensitivity and oral glucose tolerance of high‐fat diet‐induced T2DM model mice after the injection of SIS3 with 5 mg/kg for 45 days.