Clinical utility of circulating tumor DNA sequencing in advanced gastrointestinal cancer: SCRUM-Japan GI-SCREEN and GOZILA studies

Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZI...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2020-12, Vol.26 (12), p.1859-1864
Hauptverfasser:	Nakamura, Yoshiaki, Taniguchi, Hiroya, Ikeda, Masafumi, Bando, Hideaki, Kato, Ken, Morizane, Chigusa, Esaki, Taito, Komatsu, Yoshito, Kawamoto, Yasuyuki, Takahashi, Naoki, Ueno, Makoto, Kagawa, Yoshinori, Nishina, Tomohiro, Kato, Takeshi, Yamamoto, Yoshiyuki, Furuse, Junji, Denda, Tadamichi, Kawakami, Hisato, Oki, Eiji, Nakajima, Takako, Nishida, Naohiro, Yamaguchi, Kensei, Yasui, Hisateru, Goto, Masahiro, Matsuhashi, Nobuhisa, Ohtsubo, Koushiro, Yamazaki, Kentaro, Tsuji, Akihito, Okamoto, Wataru, Tsuchihara, Katsuya, Yamanaka, Takeharu, Miki, Izumi, Sakamoto, Yasutoshi, Ichiki, Hiroko, Hata, Masayuki, Yamashita, Riu, Ohtsu, Atsushi, Odegaard, Justin I., Yoshino, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/69 692/308/153 692/53/2423 Adult Biomarkers Biomarkers, Tumor - blood Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Circulating Tumor DNA - blood Circulating Tumor DNA - genetics Clinical trials Deoxyribonucleic acid Diagnosis DNA DNA sequencing DNA, Neoplasm - blood Gastrointestinal cancer Gastrointestinal Neoplasms - blood Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - pathology Genetic aspects Genotype Genotyping Health aspects High-Throughput Nucleotide Sequencing Humans Infectious Diseases Japan - epidemiology Letter Male Metabolic Diseases Middle Aged Molecular Medicine Mutation - genetics Neurosciences Nucleotide sequence Nucleotide sequencing Observational studies Oncology, Experimental Patients Precision Medicine Solid tumors Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Comprehensive genomic profiling enables genomic biomarker detection in advanced solid tumors. Here, to evaluate the utility of circulating tumor DNA (ctDNA) genotyping, we compare trial enrollment using ctDNA sequencing in 1,687 patients with advanced gastrointestinal (GI) cancer in SCRUM-Japan GOZILA (no. UMIN000016343), an observational ctDNA-based screening study, to enrollment using tumor tissue sequencing in the same centers and network (GI-SCREEN, 5,621 patients). ctDNA genotyping significantly shortened the screening duration (11 versus 33 days, P
ISSN:	1078-8956 1546-170X
DOI:	10.1038/s41591-020-1063-5