Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres
Thiazolidinones were prepared as building blocks for the replacement of carboxylic acids. Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated . The prepared compounds included the novel structure ; 5-(3-Iodophenylmethylene)-2,4-t...
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| Veröffentlicht in: | Future medicinal chemistry 2020-10, Vol.12 (20), p.1855-1864 |
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| container_title | Future medicinal chemistry |
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| creator | Scanlon, James J Wren, Stephen P |
| description | Thiazolidinones were prepared as building blocks for the replacement of carboxylic acids.
Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated
.
The prepared compounds included the novel structure
; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione.
Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs. |
| doi_str_mv | 10.4155/fmc-2020-0192 |
| format | Article |
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Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated
.
The prepared compounds included the novel structure
; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione.
Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs.</description><identifier>ISSN: 1756-8919</identifier><identifier>EISSN: 1756-8927</identifier><identifier>DOI: 10.4155/fmc-2020-0192</identifier><identifier>PMID: 33012189</identifier><language>eng</language><publisher>England: Newlands Press Ltd</publisher><subject>bioisostere ; Blood-brain barrier ; building blocks ; carboxylic acid ; Carboxylic acids ; Chemistry ; Chromatography ; Drugs ; Metabolism ; Metabolites ; Permeability ; Reagents ; thiazolidinone ; Violations</subject><ispartof>Future medicinal chemistry, 2020-10, Vol.12 (20), p.1855-1864</ispartof><rights>2020 Newlands Press</rights><rights>Copyright Newlands Press Oct 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-f3ff16bafcfa51434c16a51a050583cb1e705a02195cfa22bea82f7454d1403d3</citedby><cites>FETCH-LOGICAL-c410t-f3ff16bafcfa51434c16a51a050583cb1e705a02195cfa22bea82f7454d1403d3</cites><orcidid>0000-0001-7184-9528</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33012189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scanlon, James J</creatorcontrib><creatorcontrib>Wren, Stephen P</creatorcontrib><title>Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres</title><title>Future medicinal chemistry</title><addtitle>Future Med Chem</addtitle><description>Thiazolidinones were prepared as building blocks for the replacement of carboxylic acids.
Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated
.
The prepared compounds included the novel structure
; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione.
Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs.</description><subject>bioisostere</subject><subject>Blood-brain barrier</subject><subject>building blocks</subject><subject>carboxylic acid</subject><subject>Carboxylic acids</subject><subject>Chemistry</subject><subject>Chromatography</subject><subject>Drugs</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Permeability</subject><subject>Reagents</subject><subject>thiazolidinone</subject><subject>Violations</subject><issn>1756-8919</issn><issn>1756-8927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtLAzEURoMotqhLtzLgxs1obh4zmaUUXyC4seuQySSaOk1qMiPWX29KqwvBbO4XcvJxOQidAr5kwPmVXeqSYIJLDA3ZQ1OoeVWKhtT7vxmaCTpJaYHzoUQ0FT9EE0oxEBDNFD3NvVFxeHX-pfDhw_RFzuor9K5zPnhTtKPru81r2wf9lgqVCq1iGz7XvdOF0q4rWhdcCmkw0aRjdGBVn8zJbh6h-e3N8-y-fHy6e5hdP5aaAR5KS62FqlVWW8WBUaahykFhjrmgugVTY64wgYZngpDWKEFszTjrgGHa0SN0se1dxfA-mjTIpUva9L3yJoxJEsZERUUFkNHzP-gijNHn7SThXAAWNdBMlVtKx5BSNFauoluquJaA5Ua2zLLlRrbcyM782a51bJem-6V_1Gag2QJ2HMZsRjvjtZHbW_7htPPmn_Jv5EyNng</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Scanlon, James J</creator><creator>Wren, Stephen P</creator><general>Newlands Press Ltd</general><general>Newlands Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7184-9528</orcidid></search><sort><creationdate>20201001</creationdate><title>Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres</title><author>Scanlon, James J ; 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Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated
.
The prepared compounds included the novel structure
; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione.
Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs.</abstract><cop>England</cop><pub>Newlands Press Ltd</pub><pmid>33012189</pmid><doi>10.4155/fmc-2020-0192</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-7184-9528</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Future medicinal chemistry, 2020-10, Vol.12 (20), p.1855-1864 |
| issn | 1756-8919 1756-8927 |
| language | eng |
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| source | PubMed (Medline) |
| subjects | bioisostere Blood-brain barrier building blocks carboxylic acid Carboxylic acids Chemistry Chromatography Drugs Metabolism Metabolites Permeability Reagents thiazolidinone Violations |
| title | Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres |
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