Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres

Thiazolidinones were prepared as building blocks for the replacement of carboxylic acids. Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated . The prepared compounds included the novel structure ; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione. Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs.