Point-of-care multiplex-PCR enables germ identification in haemolytic uremic syndrome 94 h earlier than stool culture

Haemolytic uremic syndrome often affects children causing a relevant morbidity and mortality. We compared the time to diagnosis by multiplex-PCR and stool culture in 15 children from two centres. Multiplex-PCR accelerated the time to diagnosis by 94 (95% confidence interval, 80–119; P  = 0.0007) hou...

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Veröffentlicht in:European journal of clinical microbiology & infectious diseases 2021-03, Vol.40 (3), p.643-645
Hauptverfasser: Llano López, Luis Hernán, Melonari, Pablo, Gehring, Stephan, Schreiner, Daniel, Grucci, Sandra, Pérez Araujo, Sofía, Di Pauli, Lorena, Oetzmann von Sochaczewski, Christina, Schröder, Arne, Piovano, Laura
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Sprache:eng
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Zusammenfassung:Haemolytic uremic syndrome often affects children causing a relevant morbidity and mortality. We compared the time to diagnosis by multiplex-PCR and stool culture in 15 children from two centres. Multiplex-PCR accelerated the time to diagnosis by 94 (95% confidence interval, 80–119; P  = 0.0007) hours. Multiplex-PCR offers a time advantage of stool culture that may aid in earlier identification of outbreak clusters.
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-020-04060-x