COVID-19 and the kidney

COVID-19 is primarily considered a respiratory illness, but the kidney may be one of the targets of SARS-CoV-2 infection, since the virus enters cells through the angiotensin-converting enzyme 2 receptor, which is found in abundance in the kidney. Information on kidney involvement in COVID-19 is lim...

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Veröffentlicht in:	Cleveland Clinic journal of medicine 2020-10, Vol.87 (10), p.619-631
Hauptverfasser:	Hassanein, Mohamed, Radhakrishnan, Yeshwanter, Sedor, John, Vachharajani, Tushar, Vachharajani, Vidula T, Augustine, Joshua, Demirjian, Sevag, Thomas, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 Betacoronavirus - physiology Comorbidity Coronavirus Infections - epidemiology Coronavirus Infections - physiopathology Coronavirus Infections - virology Cost of Illness COVID-19 Humans Kidney Diseases - classification Kidney Diseases - epidemiology Kidney Diseases - therapy Kidney Diseases - virology Pandemics Patient Care Management - methods Peptidyl-Dipeptidase A - metabolism Pneumonia, Viral - epidemiology Pneumonia, Viral - physiopathology Pneumonia, Viral - virology SARS-CoV-2
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Beschreibung
Zusammenfassung:	COVID-19 is primarily considered a respiratory illness, but the kidney may be one of the targets of SARS-CoV-2 infection, since the virus enters cells through the angiotensin-converting enzyme 2 receptor, which is found in abundance in the kidney. Information on kidney involvement in COVID-19 is limited but is evolving rapidly. This article discusses the pathogenesis of acute kidney injury (AKI) in COVID-19, its optimal management, and the impact of COVID-19 on patients with chronic kidney disease, patients with end-stage kidney disease on dialysis, and kidney transplant recipients.
ISSN:	0891-1150 1939-2869
DOI:	10.3949/CCJM.87A.20072