Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release
The development of chitosan–gelatin (CS‐G) hydrogels embedded with ampicillin‐loaded hyaluronic acid nanoparticles (HA‐NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA‐NPs into biocompatible CS‐G hydrogel structure. According to in vi...
Gespeichert in:
| Veröffentlicht in: | Drug development research 2021-04, Vol.82 (2), p.241-250 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 250 |
|---|---|
| container_issue | 2 |
| container_start_page | 241 |
| container_title | Drug development research |
| container_volume | 82 |
| creator | Özkahraman, Bengi Tamahkar, Emel İdil, Neslihan Kılıç Suloglu, Aysun Perçin, Işık |
| description | The development of chitosan–gelatin (CS‐G) hydrogels embedded with ampicillin‐loaded hyaluronic acid nanoparticles (HA‐NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA‐NPs into biocompatible CS‐G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS‐G/HA‐NPs hydrogels after 5 days. Antibacterial performance of CS‐G/HA‐NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS‐G/HA‐NPs hydrogels compared with CS‐G group after 24 hr incubation. Consequently, the potential ability of CS‐G/HA‐NPs hydrogels as a controlled drug delivery system has been verified. |
| doi_str_mv | 10.1002/ddr.21747 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2448412774</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2509641280</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3537-44f35bf9b9314487d6d1209a6b272c73a96f463cbdb258ab52d20be73b1611d33</originalsourceid><addsrcrecordid>eNp1kMlKBDEURYMo2g4Lf0ACbnRRmqkqlaU4gyCIrkOm0kh10iZVSu_8B__QLzHa6kJw9Xhw7uG9C8A2RgcYIXJobTogmDO-BCYYibYiRIhlMEGEk4pRgdfAes6PCGHM2nYVrFGKCta0E3B_-qz6UQ0-Bhg7-DAvW4rBG6iMtzCoEGcqDd70DrqpdtY6C82DH2JW4f317d71JRxK0KZYlgy7mKAKg9c-lhhMrncqu02w0qk-u63vuQHuzk5vjy-qq-vzy-Ojq8rQmvKKsY7WuhNaUMxYy21jMUFCNbq8YjhVoulYQ422mtSt0jWxBGnHqcYNxpbSDbC38M5SfBpdHuTUZ-P6XgUXxyxJsTJMOGcF3f2DPsYxhXKdJDUSTcFaVKj9BWVSzDm5Ts6Sn6o0lxjJz_ZlaV9-tV_YnW_jqKfO_pI_dRfgcAG8-N7N_zfJk5ObhfIDlnyPsw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2509641280</pqid></control><display><type>article</type><title>Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Özkahraman, Bengi ; Tamahkar, Emel ; İdil, Neslihan ; Kılıç Suloglu, Aysun ; Perçin, Işık</creator><creatorcontrib>Özkahraman, Bengi ; Tamahkar, Emel ; İdil, Neslihan ; Kılıç Suloglu, Aysun ; Perçin, Işık</creatorcontrib><description>The development of chitosan–gelatin (CS‐G) hydrogels embedded with ampicillin‐loaded hyaluronic acid nanoparticles (HA‐NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA‐NPs into biocompatible CS‐G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS‐G/HA‐NPs hydrogels after 5 days. Antibacterial performance of CS‐G/HA‐NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS‐G/HA‐NPs hydrogels compared with CS‐G group after 24 hr incubation. Consequently, the potential ability of CS‐G/HA‐NPs hydrogels as a controlled drug delivery system has been verified.</description><identifier>ISSN: 0272-4391</identifier><identifier>EISSN: 1098-2299</identifier><identifier>DOI: 10.1002/ddr.21747</identifier><identifier>PMID: 33009868</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Ampicillin ; Ampicillin - chemical synthesis ; Ampicillin - pharmacokinetics ; Animals ; Anti-Bacterial Agents - chemical synthesis ; Anti-Bacterial Agents - pharmacology ; antibiotic release ; Antibiotics ; Antiinfectives and antibacterials ; Biocompatibility ; Cell viability ; Chitosan ; Chitosan - chemical synthesis ; Chitosan - pharmacokinetics ; chitosan–gelatin hydrogels ; Cytotoxicity ; Drug delivery ; Drug delivery systems ; Drug Evaluation, Preclinical - methods ; Drug Liberation - drug effects ; Drug Liberation - physiology ; Escherichia coli - drug effects ; Escherichia coli - physiology ; Gelatin ; Gelatin - chemical synthesis ; Gelatin - pharmacokinetics ; Humans ; Hyaluronic acid ; Hyaluronic Acid - chemical synthesis ; Hyaluronic Acid - pharmacokinetics ; hyaluronic acid nanoparticles embedding ; Hydrogels ; Hydrogels - chemical synthesis ; Hydrogels - pharmacokinetics ; Incubation ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - metabolism ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - physiology ; Toxicity testing ; Wound healing</subject><ispartof>Drug development research, 2021-04, Vol.82 (2), p.241-250</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3537-44f35bf9b9314487d6d1209a6b272c73a96f463cbdb258ab52d20be73b1611d33</citedby><cites>FETCH-LOGICAL-c3537-44f35bf9b9314487d6d1209a6b272c73a96f463cbdb258ab52d20be73b1611d33</cites><orcidid>0000-0003-1535-4381</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fddr.21747$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fddr.21747$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33009868$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Özkahraman, Bengi</creatorcontrib><creatorcontrib>Tamahkar, Emel</creatorcontrib><creatorcontrib>İdil, Neslihan</creatorcontrib><creatorcontrib>Kılıç Suloglu, Aysun</creatorcontrib><creatorcontrib>Perçin, Işık</creatorcontrib><title>Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release</title><title>Drug development research</title><addtitle>Drug Dev Res</addtitle><description>The development of chitosan–gelatin (CS‐G) hydrogels embedded with ampicillin‐loaded hyaluronic acid nanoparticles (HA‐NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA‐NPs into biocompatible CS‐G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS‐G/HA‐NPs hydrogels after 5 days. Antibacterial performance of CS‐G/HA‐NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS‐G/HA‐NPs hydrogels compared with CS‐G group after 24 hr incubation. Consequently, the potential ability of CS‐G/HA‐NPs hydrogels as a controlled drug delivery system has been verified.</description><subject>Ampicillin</subject><subject>Ampicillin - chemical synthesis</subject><subject>Ampicillin - pharmacokinetics</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>antibiotic release</subject><subject>Antibiotics</subject><subject>Antiinfectives and antibacterials</subject><subject>Biocompatibility</subject><subject>Cell viability</subject><subject>Chitosan</subject><subject>Chitosan - chemical synthesis</subject><subject>Chitosan - pharmacokinetics</subject><subject>chitosan–gelatin hydrogels</subject><subject>Cytotoxicity</subject><subject>Drug delivery</subject><subject>Drug delivery systems</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>Drug Liberation - drug effects</subject><subject>Drug Liberation - physiology</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - physiology</subject><subject>Gelatin</subject><subject>Gelatin - chemical synthesis</subject><subject>Gelatin - pharmacokinetics</subject><subject>Humans</subject><subject>Hyaluronic acid</subject><subject>Hyaluronic Acid - chemical synthesis</subject><subject>Hyaluronic Acid - pharmacokinetics</subject><subject>hyaluronic acid nanoparticles embedding</subject><subject>Hydrogels</subject><subject>Hydrogels - chemical synthesis</subject><subject>Hydrogels - pharmacokinetics</subject><subject>Incubation</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - metabolism</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - physiology</subject><subject>Toxicity testing</subject><subject>Wound healing</subject><issn>0272-4391</issn><issn>1098-2299</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMlKBDEURYMo2g4Lf0ACbnRRmqkqlaU4gyCIrkOm0kh10iZVSu_8B__QLzHa6kJw9Xhw7uG9C8A2RgcYIXJobTogmDO-BCYYibYiRIhlMEGEk4pRgdfAes6PCGHM2nYVrFGKCta0E3B_-qz6UQ0-Bhg7-DAvW4rBG6iMtzCoEGcqDd70DrqpdtY6C82DH2JW4f317d71JRxK0KZYlgy7mKAKg9c-lhhMrncqu02w0qk-u63vuQHuzk5vjy-qq-vzy-Ojq8rQmvKKsY7WuhNaUMxYy21jMUFCNbq8YjhVoulYQ422mtSt0jWxBGnHqcYNxpbSDbC38M5SfBpdHuTUZ-P6XgUXxyxJsTJMOGcF3f2DPsYxhXKdJDUSTcFaVKj9BWVSzDm5Ts6Sn6o0lxjJz_ZlaV9-tV_YnW_jqKfO_pI_dRfgcAG8-N7N_zfJk5ObhfIDlnyPsw</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Özkahraman, Bengi</creator><creator>Tamahkar, Emel</creator><creator>İdil, Neslihan</creator><creator>Kılıç Suloglu, Aysun</creator><creator>Perçin, Işık</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1535-4381</orcidid></search><sort><creationdate>202104</creationdate><title>Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release</title><author>Özkahraman, Bengi ; Tamahkar, Emel ; İdil, Neslihan ; Kılıç Suloglu, Aysun ; Perçin, Işık</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3537-44f35bf9b9314487d6d1209a6b272c73a96f463cbdb258ab52d20be73b1611d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ampicillin</topic><topic>Ampicillin - chemical synthesis</topic><topic>Ampicillin - pharmacokinetics</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>antibiotic release</topic><topic>Antibiotics</topic><topic>Antiinfectives and antibacterials</topic><topic>Biocompatibility</topic><topic>Cell viability</topic><topic>Chitosan</topic><topic>Chitosan - chemical synthesis</topic><topic>Chitosan - pharmacokinetics</topic><topic>chitosan–gelatin hydrogels</topic><topic>Cytotoxicity</topic><topic>Drug delivery</topic><topic>Drug delivery systems</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>Drug Liberation - drug effects</topic><topic>Drug Liberation - physiology</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - physiology</topic><topic>Gelatin</topic><topic>Gelatin - chemical synthesis</topic><topic>Gelatin - pharmacokinetics</topic><topic>Humans</topic><topic>Hyaluronic acid</topic><topic>Hyaluronic Acid - chemical synthesis</topic><topic>Hyaluronic Acid - pharmacokinetics</topic><topic>hyaluronic acid nanoparticles embedding</topic><topic>Hydrogels</topic><topic>Hydrogels - chemical synthesis</topic><topic>Hydrogels - pharmacokinetics</topic><topic>Incubation</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - metabolism</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - physiology</topic><topic>Toxicity testing</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Özkahraman, Bengi</creatorcontrib><creatorcontrib>Tamahkar, Emel</creatorcontrib><creatorcontrib>İdil, Neslihan</creatorcontrib><creatorcontrib>Kılıç Suloglu, Aysun</creatorcontrib><creatorcontrib>Perçin, Işık</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Drug development research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Özkahraman, Bengi</au><au>Tamahkar, Emel</au><au>İdil, Neslihan</au><au>Kılıç Suloglu, Aysun</au><au>Perçin, Işık</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release</atitle><jtitle>Drug development research</jtitle><addtitle>Drug Dev Res</addtitle><date>2021-04</date><risdate>2021</risdate><volume>82</volume><issue>2</issue><spage>241</spage><epage>250</epage><pages>241-250</pages><issn>0272-4391</issn><eissn>1098-2299</eissn><abstract>The development of chitosan–gelatin (CS‐G) hydrogels embedded with ampicillin‐loaded hyaluronic acid nanoparticles (HA‐NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA‐NPs into biocompatible CS‐G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS‐G/HA‐NPs hydrogels after 5 days. Antibacterial performance of CS‐G/HA‐NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS‐G/HA‐NPs hydrogels compared with CS‐G group after 24 hr incubation. Consequently, the potential ability of CS‐G/HA‐NPs hydrogels as a controlled drug delivery system has been verified.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33009868</pmid><doi>10.1002/ddr.21747</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1535-4381</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0272-4391 |
| ispartof | Drug development research, 2021-04, Vol.82 (2), p.241-250 |
| issn | 0272-4391 1098-2299 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2448412774 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Ampicillin Ampicillin - chemical synthesis Ampicillin - pharmacokinetics Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology antibiotic release Antibiotics Antiinfectives and antibacterials Biocompatibility Cell viability Chitosan Chitosan - chemical synthesis Chitosan - pharmacokinetics chitosan–gelatin hydrogels Cytotoxicity Drug delivery Drug delivery systems Drug Evaluation, Preclinical - methods Drug Liberation - drug effects Drug Liberation - physiology Escherichia coli - drug effects Escherichia coli - physiology Gelatin Gelatin - chemical synthesis Gelatin - pharmacokinetics Humans Hyaluronic acid Hyaluronic Acid - chemical synthesis Hyaluronic Acid - pharmacokinetics hyaluronic acid nanoparticles embedding Hydrogels Hydrogels - chemical synthesis Hydrogels - pharmacokinetics Incubation Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Toxicity testing Wound healing |
| title | Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T07%3A33%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20hyaluronic%20acid%20nanoparticle%20embedded%20chitosan%E2%80%93gelatin%20hydrogels%20for%20antibiotic%20release&rft.jtitle=Drug%20development%20research&rft.au=%C3%96zkahraman,%20Bengi&rft.date=2021-04&rft.volume=82&rft.issue=2&rft.spage=241&rft.epage=250&rft.pages=241-250&rft.issn=0272-4391&rft.eissn=1098-2299&rft_id=info:doi/10.1002/ddr.21747&rft_dat=%3Cproquest_cross%3E2509641280%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2509641280&rft_id=info:pmid/33009868&rfr_iscdi=true |