Evaluation of hyaluronic acid nanoparticle embedded chitosan–gelatin hydrogels for antibiotic release

The development of chitosan–gelatin (CS‐G) hydrogels embedded with ampicillin‐loaded hyaluronic acid nanoparticles (HA‐NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA‐NPs into biocompatible CS‐G hydrogel structure. According to in vi...

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Veröffentlicht in:	Drug development research 2021-04, Vol.82 (2), p.241-250
Hauptverfasser:	Özkahraman, Bengi, Tamahkar, Emel, İdil, Neslihan, Kılıç Suloglu, Aysun, Perçin, Işık
Format:	Artikel
Sprache:	eng
Schlagworte:	Ampicillin Ampicillin - chemical synthesis Ampicillin - pharmacokinetics Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology antibiotic release Antibiotics Antiinfectives and antibacterials Biocompatibility Cell viability Chitosan Chitosan - chemical synthesis Chitosan - pharmacokinetics chitosan–gelatin hydrogels Cytotoxicity Drug delivery Drug delivery systems Drug Evaluation, Preclinical - methods Drug Liberation - drug effects Drug Liberation - physiology Escherichia coli - drug effects Escherichia coli - physiology Gelatin Gelatin - chemical synthesis Gelatin - pharmacokinetics Humans Hyaluronic acid Hyaluronic Acid - chemical synthesis Hyaluronic Acid - pharmacokinetics hyaluronic acid nanoparticles embedding Hydrogels Hydrogels - chemical synthesis Hydrogels - pharmacokinetics Incubation Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism Staphylococcus aureus - drug effects Staphylococcus aureus - physiology Toxicity testing Wound healing
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Zusammenfassung:	The development of chitosan–gelatin (CS‐G) hydrogels embedded with ampicillin‐loaded hyaluronic acid nanoparticles (HA‐NPs) for wound dressing is proposed. It was aimed to provide controlled ampicillin delivery by incorporation of HA‐NPs into biocompatible CS‐G hydrogel structure. According to in vitro ampicillin release studies, 55% of ampicillin was released from CS‐G/HA‐NPs hydrogels after 5 days. Antibacterial performance of CS‐G/HA‐NPs hydrogels was proven with agar disc diffusion test. For cytotoxicity assay, fibroblast cell viability increased in CS‐G/HA‐NPs hydrogels compared with CS‐G group after 24 hr incubation. Consequently, the potential ability of CS‐G/HA‐NPs hydrogels as a controlled drug delivery system has been verified.
ISSN:	0272-4391 1098-2299
DOI:	10.1002/ddr.21747