Antioxidant and Antiglycation Activities of Syzygium paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus

Antioxidant and Antiglycation Activities of Syzygium paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus

Advanced glycation end-products (AGEs) may be a contributing factor in the development of diabetes-specific vascular pathologies that affect the retina, glomerulus and peripheral nerves. In this study, Australian native food plant species Syzygium paniculatum was investigated for activities relevant...

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Veröffentlicht in:Plant foods for human nutrition (Dordrecht) 2020-12, Vol.75 (4), p.621-627
Hauptverfasser: Kim, Sangseo, Semple, Susan J., Simpson, Bradley S., Deo, Permal
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Ecology
Food Science
Nutrition
Original Paper
Plant Physiology
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Zusammenfassung:Advanced glycation end-products (AGEs) may be a contributing factor in the development of diabetes-specific vascular pathologies that affect the retina, glomerulus and peripheral nerves. In this study, Australian native food plant species Syzygium paniculatum was investigated for activities relevant to Type 2 diabetes mellitus including inhibition of α -amylase, α -glucosidase and protein glycation. A methanolic extract of the leaves showed the strongest α -amylase inhibition (IC 50  = 14.29 ± 0.82 μg/mL, p  
ISSN:0921-9668
1573-9104
DOI:10.1007/s11130-020-00858-4