Analysis of the LRP10 gene in patients with Parkinson’s disease and dementia with Lewy bodies from Southern Italy

Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene in patients with PD or DLB from Southern Italy. Sequencin...

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Veröffentlicht in:	Neurological sciences 2021, Vol.42 (1), p.305-308
Hauptverfasser:	Gagliardi, Monica, Procopio, Radha, Nicoletti, Giuseppe, Morelli, Maurizio, D’Amelio, Marco, Quattrone, Aldo, Annesi, Grazia
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease Brief Communication Dementia Dementia disorders Humans Italy Lewy bodies Lewy Body Disease - genetics Medicine Medicine & Public Health Movement disorders Mutation Mutation - genetics Neurodegenerative diseases Neurology Neuroradiology Neurosciences Neurosurgery Parkinson Disease - genetics Parkinson's disease Psychiatry Sequence analysis
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Zusammenfassung:	Recently, the LRP10 gene has been associated with Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), and dementia with Lewy bodies (DLB). The aim of the present study was to evaluate the presence of mutations of the LRP10 gene in patients with PD or DLB from Southern Italy. Sequencing analysis revealed only 2 missense and 3 synonymous variants in patients and control subjects and a rare variant p.L622F in a PD case. These results suggest that LRP10 mutations are not a frequent cause of PD and DLB in Southern Italy.
ISSN:	1590-1874 1590-3478
DOI:	10.1007/s10072-020-04747-1