Differences in apoptosis levels in the different skin origin cells: Fibroblasts and keratinocytes after in vitro exposure to preservatives used in cosmetic products and present in the working environment

Differences in apoptosis levels in the different skin origin cells: Fibroblasts and keratinocytes after in vitro exposure to preservatives used in cosmetic products and present in the working environment

[Display omitted] •Senescent dermal fibroblasts much more sensitive to apoptosis than HaCaT.•During senescence fibroblasts become more sensitive to apoptosis expressed by caspase-3/7 activity.•Late-passages of fibroblasts more resistant to preservative-induced apoptosis in Annexin V test.

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Veröffentlicht in:Toxicology in vitro 2020-12, Vol.69, p.105008-105008, Article 105008
Hauptverfasser: Miranowicz-Dzierżawska, Katarzyna, Zapór, Lidia, Skowroń, Jolanta
Format: Artikel
Sprache:eng
Schlagworte:
Apoptosis
Fibroblasts
Keratinocytes
Preservatives
Working conditions
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Zusammenfassung:[Display omitted] •Senescent dermal fibroblasts much more sensitive to apoptosis than HaCaT.•During senescence fibroblasts become more sensitive to apoptosis expressed by caspase-3/7 activity.•Late-passages of fibroblasts more resistant to preservative-induced apoptosis in Annexin V test.
ISSN:0887-2333
1879-3177
DOI:10.1016/j.tiv.2020.105008