Gut microbiota in adolescent girls with polycystic ovary syndrome: Effects of randomized treatments
Summary Background Girls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS have altered gut microbiota. Objective To study the gut microbiota composition of girls with PCOS without obesity (age, 15.8 years; body mass index [BMI] 25 kg/m2) and the effects of randomized treatments...
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| Veröffentlicht in: | Pediatric obesity 2021-04, Vol.16 (4), p.e12734-n/a |
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| creator | Garcia‐Beltran, Cristina Malpique, Rita Carbonetto, Belen González‐Torres, Pedro Henares, Desirée Brotons, Pedro Muñoz‐Almagro, Carmen López‐Bermejo, Abel Zegher, Francis Ibáñez, Lourdes |
| description | Summary
Background
Girls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS have altered gut microbiota.
Objective
To study the gut microbiota composition of girls with PCOS without obesity (age, 15.8 years; body mass index [BMI] 25 kg/m2) and the effects of randomized treatments with an oral contraceptive (OC, N = 15) or with spironolactone‐pioglitazone‐metformin (SPIOMET, N = 15) for 1 year. Thirty‐one age‐matched girls served as controls.
Methods
16S ribosomal subunit gene amplicon sequencing was performed in stool samples from all subjects; samples from 23 out of 30 girls with PCOS (OC, N = 12; SPIOMET, N = 11) were available for analysis post‐treatment. Clinical and endocrine‐metabolic variables were measured before and after intervention.
Results
Girls with PCOS had decreased diversity alpha, altered microbiota pattern and taxonomic profile with more abundance of Family XI (P = .002), and less abundance of family Prevotellaceae (P = .0006) the genus Prevotella (P = .0001) and Senegalimassilia (P |
| doi_str_mv | 10.1111/ijpo.12734 |
| format | Article |
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Background
Girls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS have altered gut microbiota.
Objective
To study the gut microbiota composition of girls with PCOS without obesity (age, 15.8 years; body mass index [BMI] 25 kg/m2) and the effects of randomized treatments with an oral contraceptive (OC, N = 15) or with spironolactone‐pioglitazone‐metformin (SPIOMET, N = 15) for 1 year. Thirty‐one age‐matched girls served as controls.
Methods
16S ribosomal subunit gene amplicon sequencing was performed in stool samples from all subjects; samples from 23 out of 30 girls with PCOS (OC, N = 12; SPIOMET, N = 11) were available for analysis post‐treatment. Clinical and endocrine‐metabolic variables were measured before and after intervention.
Results
Girls with PCOS had decreased diversity alpha, altered microbiota pattern and taxonomic profile with more abundance of Family XI (P = .002), and less abundance of family Prevotellaceae (P = .0006) the genus Prevotella (P = .0001) and Senegalimassilia (P < .0001), as compared to controls. Family XI abundance related positively to hepato‐visceral fat (R = 0.453; P = .0003). SPIOMET treatment, but not OC, normalized the abundance of Family XI. Prevotellaceae, Prevotella and Senegalimassilia abundance remained unchanged after either treatment.
Conclusion
SPIOMET's spectrum of normalizing effects in girls with PCOS is herewith broadened as to include Family XI abundance in gut microbiota.</description><identifier>ISSN: 2047-6302</identifier><identifier>EISSN: 2047-6310</identifier><identifier>DOI: 10.1111/ijpo.12734</identifier><identifier>PMID: 32989872</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Inc</publisher><subject>Antidiabetics ; Childrens health ; Girls ; gut microbiota ; hepatic fat ; metformin ; Microbiota ; Obesity ; Ovaries ; PCOS ; Pediatrics ; pioglitazone ; Polycystic ovary syndrome ; spironolactone</subject><ispartof>Pediatric obesity, 2021-04, Vol.16 (4), p.e12734-n/a</ispartof><rights>2020 World Obesity Federation</rights><rights>2020 World Obesity Federation.</rights><rights>2021 World Obesity Federation</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3574-db4b6796d7460598d3f1bcc89fd85b3719ebb3ad270c39be358b215e866626603</citedby><cites>FETCH-LOGICAL-c3574-db4b6796d7460598d3f1bcc89fd85b3719ebb3ad270c39be358b215e866626603</cites><orcidid>0000-0002-5828-8911</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijpo.12734$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijpo.12734$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32989872$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garcia‐Beltran, Cristina</creatorcontrib><creatorcontrib>Malpique, Rita</creatorcontrib><creatorcontrib>Carbonetto, Belen</creatorcontrib><creatorcontrib>González‐Torres, Pedro</creatorcontrib><creatorcontrib>Henares, Desirée</creatorcontrib><creatorcontrib>Brotons, Pedro</creatorcontrib><creatorcontrib>Muñoz‐Almagro, Carmen</creatorcontrib><creatorcontrib>López‐Bermejo, Abel</creatorcontrib><creatorcontrib>Zegher, Francis</creatorcontrib><creatorcontrib>Ibáñez, Lourdes</creatorcontrib><title>Gut microbiota in adolescent girls with polycystic ovary syndrome: Effects of randomized treatments</title><title>Pediatric obesity</title><addtitle>Pediatr Obes</addtitle><description>Summary
Background
Girls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS have altered gut microbiota.
Objective
To study the gut microbiota composition of girls with PCOS without obesity (age, 15.8 years; body mass index [BMI] 25 kg/m2) and the effects of randomized treatments with an oral contraceptive (OC, N = 15) or with spironolactone‐pioglitazone‐metformin (SPIOMET, N = 15) for 1 year. Thirty‐one age‐matched girls served as controls.
Methods
16S ribosomal subunit gene amplicon sequencing was performed in stool samples from all subjects; samples from 23 out of 30 girls with PCOS (OC, N = 12; SPIOMET, N = 11) were available for analysis post‐treatment. Clinical and endocrine‐metabolic variables were measured before and after intervention.
Results
Girls with PCOS had decreased diversity alpha, altered microbiota pattern and taxonomic profile with more abundance of Family XI (P = .002), and less abundance of family Prevotellaceae (P = .0006) the genus Prevotella (P = .0001) and Senegalimassilia (P < .0001), as compared to controls. Family XI abundance related positively to hepato‐visceral fat (R = 0.453; P = .0003). SPIOMET treatment, but not OC, normalized the abundance of Family XI. Prevotellaceae, Prevotella and Senegalimassilia abundance remained unchanged after either treatment.
Conclusion
SPIOMET's spectrum of normalizing effects in girls with PCOS is herewith broadened as to include Family XI abundance in gut microbiota.</description><subject>Antidiabetics</subject><subject>Childrens health</subject><subject>Girls</subject><subject>gut microbiota</subject><subject>hepatic fat</subject><subject>metformin</subject><subject>Microbiota</subject><subject>Obesity</subject><subject>Ovaries</subject><subject>PCOS</subject><subject>Pediatrics</subject><subject>pioglitazone</subject><subject>Polycystic ovary syndrome</subject><subject>spironolactone</subject><issn>2047-6302</issn><issn>2047-6310</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LwzAYgIMobsxd_AES8CLCNB9t0ngTmToZ6EHPpfmoZrTNTFKl_nrjph48-F7eHB4e8j4AHGJ0htOc29XanWHCabYDxgRlfMYoRru_b0RGYBrCCqVhCDOU7YMRJaIQBSdjoG76CFurvJPWxQraDlbaNSYo00X4bH0T4LuNL3DtmkENIVoF3VvlBxiGTnvXmgs4r2ujYoCuhr7qtGvth9EwelPFNlnCAdirqyaY6feegKfr-ePV7Wx5f7O4ulzOFM15NtMyk4wLpnnGUC4KTWsslSpErYtcUo6FkZJWmnCkqJCG5oUkODcFY4wwhugEnGy9a-9eexNi2dp0R9NUnXF9KEmWcYoKQfKEHv9BV673XfpdokSeC0Y3wtMtlfKE4E1drr1t0_ElRuVX_fKrfrmpn-Cjb2UvW6N_0Z_WCcBb4N02ZvhHVS7uHu630k9Hw4-Z</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Garcia‐Beltran, Cristina</creator><creator>Malpique, Rita</creator><creator>Carbonetto, Belen</creator><creator>González‐Torres, Pedro</creator><creator>Henares, Desirée</creator><creator>Brotons, Pedro</creator><creator>Muñoz‐Almagro, Carmen</creator><creator>López‐Bermejo, Abel</creator><creator>Zegher, Francis</creator><creator>Ibáñez, Lourdes</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5828-8911</orcidid></search><sort><creationdate>202104</creationdate><title>Gut microbiota in adolescent girls with polycystic ovary syndrome: Effects of randomized treatments</title><author>Garcia‐Beltran, Cristina ; Malpique, Rita ; Carbonetto, Belen ; González‐Torres, Pedro ; Henares, Desirée ; Brotons, Pedro ; Muñoz‐Almagro, Carmen ; López‐Bermejo, Abel ; Zegher, Francis ; Ibáñez, Lourdes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3574-db4b6796d7460598d3f1bcc89fd85b3719ebb3ad270c39be358b215e866626603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Antidiabetics</topic><topic>Childrens health</topic><topic>Girls</topic><topic>gut microbiota</topic><topic>hepatic fat</topic><topic>metformin</topic><topic>Microbiota</topic><topic>Obesity</topic><topic>Ovaries</topic><topic>PCOS</topic><topic>Pediatrics</topic><topic>pioglitazone</topic><topic>Polycystic ovary syndrome</topic><topic>spironolactone</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garcia‐Beltran, Cristina</creatorcontrib><creatorcontrib>Malpique, Rita</creatorcontrib><creatorcontrib>Carbonetto, Belen</creatorcontrib><creatorcontrib>González‐Torres, Pedro</creatorcontrib><creatorcontrib>Henares, Desirée</creatorcontrib><creatorcontrib>Brotons, Pedro</creatorcontrib><creatorcontrib>Muñoz‐Almagro, Carmen</creatorcontrib><creatorcontrib>López‐Bermejo, Abel</creatorcontrib><creatorcontrib>Zegher, Francis</creatorcontrib><creatorcontrib>Ibáñez, Lourdes</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garcia‐Beltran, Cristina</au><au>Malpique, Rita</au><au>Carbonetto, Belen</au><au>González‐Torres, Pedro</au><au>Henares, Desirée</au><au>Brotons, Pedro</au><au>Muñoz‐Almagro, Carmen</au><au>López‐Bermejo, Abel</au><au>Zegher, Francis</au><au>Ibáñez, Lourdes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gut microbiota in adolescent girls with polycystic ovary syndrome: Effects of randomized treatments</atitle><jtitle>Pediatric obesity</jtitle><addtitle>Pediatr Obes</addtitle><date>2021-04</date><risdate>2021</risdate><volume>16</volume><issue>4</issue><spage>e12734</spage><epage>n/a</epage><pages>e12734-n/a</pages><issn>2047-6302</issn><eissn>2047-6310</eissn><abstract>Summary
Background
Girls with obesity and polycystic ovary syndrome (PCOS) and women with PCOS have altered gut microbiota.
Objective
To study the gut microbiota composition of girls with PCOS without obesity (age, 15.8 years; body mass index [BMI] 25 kg/m2) and the effects of randomized treatments with an oral contraceptive (OC, N = 15) or with spironolactone‐pioglitazone‐metformin (SPIOMET, N = 15) for 1 year. Thirty‐one age‐matched girls served as controls.
Methods
16S ribosomal subunit gene amplicon sequencing was performed in stool samples from all subjects; samples from 23 out of 30 girls with PCOS (OC, N = 12; SPIOMET, N = 11) were available for analysis post‐treatment. Clinical and endocrine‐metabolic variables were measured before and after intervention.
Results
Girls with PCOS had decreased diversity alpha, altered microbiota pattern and taxonomic profile with more abundance of Family XI (P = .002), and less abundance of family Prevotellaceae (P = .0006) the genus Prevotella (P = .0001) and Senegalimassilia (P < .0001), as compared to controls. Family XI abundance related positively to hepato‐visceral fat (R = 0.453; P = .0003). SPIOMET treatment, but not OC, normalized the abundance of Family XI. Prevotellaceae, Prevotella and Senegalimassilia abundance remained unchanged after either treatment.
Conclusion
SPIOMET's spectrum of normalizing effects in girls with PCOS is herewith broadened as to include Family XI abundance in gut microbiota.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Inc</pub><pmid>32989872</pmid><doi>10.1111/ijpo.12734</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5828-8911</orcidid></addata></record> |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Antidiabetics Childrens health Girls gut microbiota hepatic fat metformin Microbiota Obesity Ovaries PCOS Pediatrics pioglitazone Polycystic ovary syndrome spironolactone |
| title | Gut microbiota in adolescent girls with polycystic ovary syndrome: Effects of randomized treatments |
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