The biochemistry of lanthanide acquisition, trafficking, and utilization

Lanthanides are relative newcomers to the field of cell biology of metals; their specific incorporation into enzymes was only demonstrated in 2011, with the isolation of a bacterial lanthanide- and pyrroloquinoline quinone-dependent methanol dehydrogenase. Since that discovery, the efforts of many investigators have revealed that lanthanide utilization is widespread in environmentally important bacteria, and parallel efforts have focused on elucidating the molecular details involved in selective recognition and utilization of these metals. In this review, we discuss the particular chemical challenges and advantages associated with biology's use of lanthanides, as well as the currently known lanthano-enzymes and -proteins (the lanthanome). We also review the emerging understanding of the coordination chemistry and biology of lanthanide acquisition, trafficking, and regulatory pathways. These studies have revealed significant parallels with pathways for utilization of other metals in biology. Finally, we discuss some of the many unresolved questions in this burgeoning field and their potentially far-reaching applications. [Display omitted] •Lanthanides catalyze essential reactions in methylotrophic and other bacteria.•Genetic and biochemical studies have revealed multiple lanthanide-linked pathways.•Lanthanides are selectively acquired, trafficked, and stored by cells.•Natural chelators have highlighted principles of selective lanthanide recognition.•Characterizing lanthanide biochemistry has applications from mining to medicine.