Association Between Estimated Glomerular Filtration Rate Based on Cystatin C and Grip Strength in Community-Dwelling Japanese Older Adults

Abstract Background Kidney dysfunction is associated with sarcopenia. Estimated glomerular filtration rate based on cystatin C (eGFRcys), an alternative to creatinine-based measures of kidney function eGFR, is not affected by muscle mass. Given that the association of eGFRcys with muscle weakness wo...

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Veröffentlicht in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2021-09, Vol.76 (9), p.1653-1660
Hauptverfasser: Kabasawa, Keiko, Nakamura, Kazutoshi, Ito, Yumi, Tanaka, Junta, Narita, Ichiei
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Sprache:eng
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Zusammenfassung:Abstract Background Kidney dysfunction is associated with sarcopenia. Estimated glomerular filtration rate based on cystatin C (eGFRcys), an alternative to creatinine-based measures of kidney function eGFR, is not affected by muscle mass. Given that the association of eGFRcys with muscle weakness would be limited, we examined the association in older adults with normal or compromised kidney function. Methods This cross-sectional study involved 594 community-dwelling Japanese adults aged ≥40 years living in Yuzawa, Japan. Serum creatinine, cystatin C, and handgrip strength were concurrently measured at a health-check examination in 2015. eGFR was calculated according to the equation developed for the Japanese population using creatinine and cystatin C. Associations of eGFRcys and eGFRcreat with low grip strength (men,
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glaa240