Structure elucidation of a new triterpene from Inonotus obliquus

Ethyl acetate (EtOAc) fraction of the Inonotus obliquus (Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)–induced murine BV2 microglial cells. A new triterpene, characterized as inonotusol H (1), was isolated from the EtOAc fraction using the bioactivity‐...

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Veröffentlicht in:Magnetic resonance in chemistry 2021-04, Vol.59 (4), p.489-494
Hauptverfasser: Park, Sangmin, Shin, Hyeji, Park, Dawon, Kim, Hyunwoo, Byun, Youngjoo, Lee, Ki Yong
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Sprache:eng
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Zusammenfassung:Ethyl acetate (EtOAc) fraction of the Inonotus obliquus (Hymenochaetaceae) significantly inhibited nitric oxide production in lipopolysaccharide (LPS)–induced murine BV2 microglial cells. A new triterpene, characterized as inonotusol H (1), was isolated from the EtOAc fraction using the bioactivity‐guided fractionation together with four known triterpenes, inotodiol (2), trametenolic acid (3), inonotsutriols A (4), and inonotusol A (5). Among them, Compounds 2–4 significantly reduced LPS‐induced nitric oxide production to 4.5 ± 0.8%, 47.4 ± 4.4%, and 2.8 ± 1.7%, respectively, at a concentration of 30 μM.
ISSN:0749-1581
1097-458X
DOI:10.1002/mrc.5102