Circulating adiponectin levels and systemic lupus erythematosus: a two-sample Mendelian randomization study

Abstract Objectives Several studies have reported increased serum/plasma adiponectin levels in SLE patients. This study was performed to estimate the causal effects of circulating adiponectin levels on SLE. Methods We selected nine independent single-nucleotide polymorphisms that were associated wit...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2021-02, Vol.60 (2), p.940-946
Hauptverfasser:	Dan, Yi-Lin, Wang, Peng, Cheng, Zhongle, Wu, Qian, Wang, Xue-Rong, Wang, De-Guang, Pan, Hai-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adiponectin - blood Adiponectin - genetics Correlation of Data Genome-Wide Association Study Humans Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - epidemiology Mendelian Randomization Analysis Polymorphism, Single Nucleotide Risk Assessment - methods
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Zusammenfassung:	Abstract Objectives Several studies have reported increased serum/plasma adiponectin levels in SLE patients. This study was performed to estimate the causal effects of circulating adiponectin levels on SLE. Methods We selected nine independent single-nucleotide polymorphisms that were associated with circulating adiponectin levels (P
ISSN:	1462-0324 1462-0332
DOI:	10.1093/rheumatology/keaa506