Benzotetramisole catalyzed kinetic resolution of 2H-azirines

Benzotetramisole catalyzed kinetic resolution of 2H-azirines

An unprecedented benzotetramisole (BTM)-catalyzed kinetic resolution for the efficient synthesis of chiral 2H-azirines is described. This protocol provides two chiral isomers in one step with broad scope, good yield and high enantioselectivity. In addition, the optically pure 2H-azirine products hav...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2020-10, Vol.56 (82), p.12427-12430
Hauptverfasser: Peng, Qiupeng, Guo, Donghui, Zhang, Bei, Liu, Lala, Wang, Jian
Format: Artikel
Sprache:eng
Schlagworte:
Crystallography
Enantiomers
Isomers
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Zusammenfassung:An unprecedented benzotetramisole (BTM)-catalyzed kinetic resolution for the efficient synthesis of chiral 2H-azirines is described. This protocol provides two chiral isomers in one step with broad scope, good yield and high enantioselectivity. In addition, the optically pure 2H-azirine products have proven to be useful building blocks for further synthetic transformations.
ISSN:1359-7345
1364-548X
DOI:10.1039/d0cc05379a