In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves
[Display omitted] •Angiogenesis is a “hallmark” of cancer.•Extracts from Spondias mombin L. have shown a wide range of biological effects.•Phenols are important components that may play a role in those biological effects.•Effects of the extracts were tested in several biological assays.•Extracts hav...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2020-11, Vol.131, p.110716-110716, Article 110716 |
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| container_title | Biomedicine & pharmacotherapy |
| container_volume | 131 |
| creator | Rey-Blanes, Cristina Pérez-Portero, Yalina Morris-Quevedo, Humberto J. Casas, Virginia Abdala, Roberto Quesada, Ana R. Martínez-Poveda, Beatriz Medina, Miguel Ángel |
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•Angiogenesis is a “hallmark” of cancer.•Extracts from Spondias mombin L. have shown a wide range of biological effects.•Phenols are important components that may play a role in those biological effects.•Effects of the extracts were tested in several biological assays.•Extracts have displayed an effect over cellssurvival and angiogenetic potential.
The traditional ethnobotanic and pharmacologic use of Spondias mombin L. samples includes a wide range of applications. In the present study, new antiangiogenic and antitumor effects of two types of extracts from Spondias mombin L. leaves have been demonstrated by using a number of in vitro assays in both endothelial and human cancer and non cancer cells. |
| doi_str_mv | 10.1016/j.biopha.2020.110716 |
| format | Article |
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•Angiogenesis is a “hallmark” of cancer.•Extracts from Spondias mombin L. have shown a wide range of biological effects.•Phenols are important components that may play a role in those biological effects.•Effects of the extracts were tested in several biological assays.•Extracts have displayed an effect over cellssurvival and angiogenetic potential.
The traditional ethnobotanic and pharmacologic use of Spondias mombin L. samples includes a wide range of applications. In the present study, new antiangiogenic and antitumor effects of two types of extracts from Spondias mombin L. leaves have been demonstrated by using a number of in vitro assays in both endothelial and human cancer and non cancer cells.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2020.110716</identifier><identifier>PMID: 32920516</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Anacardiaceae - chemistry ; Angiogenesis ; Angiogenesis Inhibitors - pharmacology ; Antiangiogenic effects ; Antineoplastic Agents, Phytogenic - pharmacology ; Antitumor effects ; Cell Cycle - drug effects ; Cell Line, Tumor ; Cell Movement - drug effects ; Cell Survival - drug effects ; Endothelial Cells - drug effects ; Humans ; Plant Extracts - pharmacology ; Plant Leaves - chemistry ; Spondias mombin</subject><ispartof>Biomedicine & pharmacotherapy, 2020-11, Vol.131, p.110716-110716, Article 110716</ispartof><rights>2020 The Authors</rights><rights>Copyright © 2020 The Authors. Published by Elsevier Masson SAS.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-f891cbd3fa78db306bea74bdfe169dbd1a2d9e1b030f2ffc07b91433ab50714f3</citedby><cites>FETCH-LOGICAL-c408t-f891cbd3fa78db306bea74bdfe169dbd1a2d9e1b030f2ffc07b91433ab50714f3</cites><orcidid>0000-0001-7275-6462</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2020.110716$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32920516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rey-Blanes, Cristina</creatorcontrib><creatorcontrib>Pérez-Portero, Yalina</creatorcontrib><creatorcontrib>Morris-Quevedo, Humberto J.</creatorcontrib><creatorcontrib>Casas, Virginia</creatorcontrib><creatorcontrib>Abdala, Roberto</creatorcontrib><creatorcontrib>Quesada, Ana R.</creatorcontrib><creatorcontrib>Martínez-Poveda, Beatriz</creatorcontrib><creatorcontrib>Medina, Miguel Ángel</creatorcontrib><title>In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>[Display omitted]
•Angiogenesis is a “hallmark” of cancer.•Extracts from Spondias mombin L. have shown a wide range of biological effects.•Phenols are important components that may play a role in those biological effects.•Effects of the extracts were tested in several biological assays.•Extracts have displayed an effect over cellssurvival and angiogenetic potential.
The traditional ethnobotanic and pharmacologic use of Spondias mombin L. samples includes a wide range of applications. In the present study, new antiangiogenic and antitumor effects of two types of extracts from Spondias mombin L. leaves have been demonstrated by using a number of in vitro assays in both endothelial and human cancer and non cancer cells.</description><subject>Anacardiaceae - chemistry</subject><subject>Angiogenesis</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Antiangiogenic effects</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Antitumor effects</subject><subject>Cell Cycle - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Cell Survival - drug effects</subject><subject>Endothelial Cells - drug effects</subject><subject>Humans</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves - chemistry</subject><subject>Spondias mombin</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEuLFDEQgIMo7rj6D0Ry9NJjJennRZBl1YUBD-o55FHZzdCdjEl60H9vxl49eqoHX1VRHyGvGewZsP7dca99PD2oPQdeWwwG1j8hOzZ10PQAw1Oyg6ETjRCcX5EXOR8BoOvF-JxcCT5x6Fi_I_NdoGdfUqR4VvOqio-BRkfLA1IVii_rEpOaa27_1Crc-3iPwRuKzqEp-ULjz5LUJXcpLvTrKQbrVaZLXLQP9LCnM6oz5pfkmVNzxleP8Zp8_3j77eZzc_jy6e7mw6ExLYylcePEjLbCqWG0WkCvUQ2ttg5ZP1ltmeJ2QqZBgOPOGRj0xFohlO6qhNaJa_J223tK8ceKucjFZ4PzrALGNUvetrwq6sa2ou2GmhRzTujkKflFpV-Sgbx4lke5eZYXz3LzXMfePF5Y9YL239BfsRV4vwFY_zx7TDIbj8Gg9alakzb6_1_4Dd0Mkhg</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Rey-Blanes, Cristina</creator><creator>Pérez-Portero, Yalina</creator><creator>Morris-Quevedo, Humberto J.</creator><creator>Casas, Virginia</creator><creator>Abdala, Roberto</creator><creator>Quesada, Ana R.</creator><creator>Martínez-Poveda, Beatriz</creator><creator>Medina, Miguel Ángel</creator><general>Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7275-6462</orcidid></search><sort><creationdate>202011</creationdate><title>In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves</title><author>Rey-Blanes, Cristina ; Pérez-Portero, Yalina ; Morris-Quevedo, Humberto J. ; Casas, Virginia ; Abdala, Roberto ; Quesada, Ana R. ; Martínez-Poveda, Beatriz ; Medina, Miguel Ángel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-f891cbd3fa78db306bea74bdfe169dbd1a2d9e1b030f2ffc07b91433ab50714f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anacardiaceae - chemistry</topic><topic>Angiogenesis</topic><topic>Angiogenesis Inhibitors - pharmacology</topic><topic>Antiangiogenic effects</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Antitumor effects</topic><topic>Cell Cycle - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Cell Survival - drug effects</topic><topic>Endothelial Cells - drug effects</topic><topic>Humans</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves - chemistry</topic><topic>Spondias mombin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rey-Blanes, Cristina</creatorcontrib><creatorcontrib>Pérez-Portero, Yalina</creatorcontrib><creatorcontrib>Morris-Quevedo, Humberto J.</creatorcontrib><creatorcontrib>Casas, Virginia</creatorcontrib><creatorcontrib>Abdala, Roberto</creatorcontrib><creatorcontrib>Quesada, Ana R.</creatorcontrib><creatorcontrib>Martínez-Poveda, Beatriz</creatorcontrib><creatorcontrib>Medina, Miguel Ángel</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rey-Blanes, Cristina</au><au>Pérez-Portero, Yalina</au><au>Morris-Quevedo, Humberto J.</au><au>Casas, Virginia</au><au>Abdala, Roberto</au><au>Quesada, Ana R.</au><au>Martínez-Poveda, Beatriz</au><au>Medina, Miguel Ángel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2020-11</date><risdate>2020</risdate><volume>131</volume><spage>110716</spage><epage>110716</epage><pages>110716-110716</pages><artnum>110716</artnum><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>[Display omitted]
•Angiogenesis is a “hallmark” of cancer.•Extracts from Spondias mombin L. have shown a wide range of biological effects.•Phenols are important components that may play a role in those biological effects.•Effects of the extracts were tested in several biological assays.•Extracts have displayed an effect over cellssurvival and angiogenetic potential.
The traditional ethnobotanic and pharmacologic use of Spondias mombin L. samples includes a wide range of applications. In the present study, new antiangiogenic and antitumor effects of two types of extracts from Spondias mombin L. leaves have been demonstrated by using a number of in vitro assays in both endothelial and human cancer and non cancer cells.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>32920516</pmid><doi>10.1016/j.biopha.2020.110716</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7275-6462</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anacardiaceae - chemistry Angiogenesis Angiogenesis Inhibitors - pharmacology Antiangiogenic effects Antineoplastic Agents, Phytogenic - pharmacology Antitumor effects Cell Cycle - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Survival - drug effects Endothelial Cells - drug effects Humans Plant Extracts - pharmacology Plant Leaves - chemistry Spondias mombin |
| title | In vitro evaluation of the antitumoral and antiangiogenic effects of extracts from Spondias mombin L. leaves |
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