Tumor microenvironment conditions that favor vessel co-option in colorectal cancer liver metastases: A theoretical model

Vessel co-option is an alternative strategy by which tumour cells vascularize and gain access to nutrients to support tumour growth, survival and metastasis. In vessel co-option, the cancer cells move towards the pre-existing vasculature and hijack them. Vessel co-option is adopted by a wide range o...

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Veröffentlicht in:Seminars in cancer biology 2021-06, Vol.71, p.52-64
Hauptverfasser: Rada, Miran, Lazaris, Anthoula, Kapelanski-Lamoureux, Audrey, Mayer, Thomas Z., Metrakos, Peter
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Sprache:eng
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Zusammenfassung:Vessel co-option is an alternative strategy by which tumour cells vascularize and gain access to nutrients to support tumour growth, survival and metastasis. In vessel co-option, the cancer cells move towards the pre-existing vasculature and hijack them. Vessel co-option is adopted by a wide range of human tumours including colorectal cancer liver metastases (CRCLM) and is responsible for the effectiveness of treatment in CRCLM. Furthermore, vessel co-option is an intrinsic feature and an acquired mechanism of resistance to anti-angiogenic treatment. In this review, we describe the microenvironment, the molecular players, discovered thus far of co-opting CRCLM lesions and propose a theoretical model. We also highlight key unanswered questions that are critical to improving our understanding of CRCLM vessel co-option and for the development of effective approaches for the treatment of co-opting tumours.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2020.09.001