Long-term Follow-up of Intravesical Onabotulinum Toxin-A Injections in Male Patients with Idiopathic Overactive Bladder: Comparing Surgery-naïve Patients and Patients After Prostate Surgery

Evidence regarding long-term results in male idiopathic overactive bladder (iOAB) patients is limited and rarely focuses on the effects of prior prostatic surgery. This study aims to identify the long-term treatment persistency and occurrence of adverse events of intravesical onabotulinum toxin-A (B...

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Veröffentlicht in:European urology focus 2021-11, Vol.7 (6), p.1424-1429
Hauptverfasser: Bels, Julia, de Vries, Peter, de Beij, Jeltje, Marcelissen, Tom, van Koeveringe, Gommert, Rademakers, Kevin
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Sprache:eng
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Zusammenfassung:Evidence regarding long-term results in male idiopathic overactive bladder (iOAB) patients is limited and rarely focuses on the effects of prior prostatic surgery. This study aims to identify the long-term treatment persistency and occurrence of adverse events of intravesical onabotulinum toxin-A (BoNT-A) injections in male iOAB patients after prostatic surgery (ie, transurethral resection of the prostate [TURP] or radical prostatectomy [RP]) compared with surgery-naïve patients. In this retrospective, single-centre study, data from 477 patients treated with intravesical BoNT-A injections were collected. Outcome data of 120 male patients with iOAB, with collectively 207 BoNT-A injections, were analysed and presented in this study. At the last point of follow-up, 35 patients (29.2%) were still on active treatment. Twenty patients (16.7%) required de novo clean intermittent self-catheterisation (CISC). Three groups were identified: 56 patients without prostate surgery, 40 patients with TURP, and 24 patients with RP prior to treatment. Discontinuation rates and patient-reported outcomes of BoNT-A treatment (none, insufficient, or satisfactory) were similar, but a significant difference was seen in de novo CISC (p=0.004): 28.6% in the group without prior surgery, 7.5% in the TURP subgroup, and 4.2% in the RP subgroup. Odds of de novo CISC was significantly higher for the group without prior surgery than for both the TURP subgroup (odds ratio [OR] 4.9; 95% confidence interval [CI]: 1.33–18.31; p=0.017) and the RP subgroup (OR 9.2; 95% CI: 1.14–73.96; p= 0.037). The data of this retrospective, single-centre cohort suggest that BoNT-A treatment leads to lower CISC rates in male patients after prior desobstructive surgery than in surgery-naïve patients. This study describes the results of onabotulinum toxin-A (BoNT-A) injections in the bladder of male patients with idiopathic overactive bladder after initial prostate surgery compared with surgery-naïve patients. The results showed that BoNT-A treatment leads to lower catheterisation rates in patients after prior prostate surgery than in men without prior prostate surgery. The data of this retrospective, single-centre, cohort study suggest that onabotulinum toxin-A injection leads to lower clean intermittent self-catheterisation rates in male patients after prior desobstructive surgery than in surgery-naïve patients.
ISSN:2405-4569
2405-4569
DOI:10.1016/j.euf.2020.08.015