Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells
A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated....
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2020-08, Vol.169 (4), p.508-511 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Gudkova, O. I. Demchenko, A. G. Shvets, A. V. Kuryakov, V. N. Sedyakina, N. E. Lyundup, A. V. Feldman, N. B. Gromovykh, T. I. Lutsenko, S. V. |
| description | A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated. Nanoparticles with a low concentration of agaricinic acid stimulated and with high concentration — suppressed metabolic activity and viability of hepatoma cells. The EC
50
for the stimulating effect was 32.8 μg/ml, and the IC
50
=602.1 mg/ml. The preparation of agaricinic acid nanoparticles can be used in medicine as a potential antitumor agent. |
| doi_str_mv | 10.1007/s10517-020-04919-1 |
| format | Article |
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50
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50
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50
for the stimulating effect was 32.8 μg/ml, and the IC
50
=602.1 mg/ml. The preparation of agaricinic acid nanoparticles can be used in medicine as a potential antitumor agent.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Hepatoma</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Nanoparticles</subject><subject>Pathology</subject><subject>Permeability</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNks-L1DAcxYMoOK7-A54Kgnjpml9N0-M46I6w6EXxGL6TSbpZ0mRMUmH_e1PrYRZkkBySPD7vJSQPodcEXxOM-_eZ4I70Laa4xXwgQ0ueoA3petZKSslTtMGVarmU8jl6kfP9ssWCbNCPDy76ODoNvtnq4n658tBE22xHSE674HSV3bH5AiGeIBWnvckNjOBCLs1-niA0e3OCEidYFje02Rnv80v0zILP5tXf-Qp9__Tx227f3n69-bzb3raa96S0lnQYBiEtO1IJkmMscC8xHaCjZDhIwzpLey7JgXZCVBE6PGB50EC55VayK_RuzT2l-HM2uajJZV1vAMHEOSvKORGE9WKo6JsVHcEb5YKNJYFecLUVkvYD5YxdprioL8g6Uqnrf1B1HM3kdAzGuqo_iv0_w9kJb88MdwZ8ucvRz8XFkB8nXwbPEukK6hRzTsaqU3ITpAdFsFpapNYWqdoi9adFajGx1ZQrHEaT1H2cU6hfesn1G8rww3w</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Gudkova, O. I.</creator><creator>Demchenko, A. G.</creator><creator>Shvets, A. V.</creator><creator>Kuryakov, V. N.</creator><creator>Sedyakina, N. E.</creator><creator>Lyundup, A. V.</creator><creator>Feldman, N. B.</creator><creator>Gromovykh, T. I.</creator><creator>Lutsenko, S. V.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200801</creationdate><title>Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells</title><author>Gudkova, O. I. ; Demchenko, A. G. ; Shvets, A. V. ; Kuryakov, V. N. ; Sedyakina, N. E. ; Lyundup, A. V. ; Feldman, N. B. ; Gromovykh, T. I. ; Lutsenko, S. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-f150a968f3d28a84006078029a5219b8e35f27481b2566a52a50908bca24f4f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Hepatoma</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Nanoparticles</topic><topic>Pathology</topic><topic>Permeability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gudkova, O. I.</creatorcontrib><creatorcontrib>Demchenko, A. G.</creatorcontrib><creatorcontrib>Shvets, A. V.</creatorcontrib><creatorcontrib>Kuryakov, V. N.</creatorcontrib><creatorcontrib>Sedyakina, N. E.</creatorcontrib><creatorcontrib>Lyundup, A. V.</creatorcontrib><creatorcontrib>Feldman, N. B.</creatorcontrib><creatorcontrib>Gromovykh, T. I.</creatorcontrib><creatorcontrib>Lutsenko, S. V.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gudkova, O. I.</au><au>Demchenko, A. G.</au><au>Shvets, A. V.</au><au>Kuryakov, V. N.</au><au>Sedyakina, N. E.</au><au>Lyundup, A. V.</au><au>Feldman, N. B.</au><au>Gromovykh, T. I.</au><au>Lutsenko, S. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><date>2020-08-01</date><risdate>2020</risdate><volume>169</volume><issue>4</issue><spage>508</spage><epage>511</epage><pages>508-511</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated. Nanoparticles with a low concentration of agaricinic acid stimulated and with high concentration — suppressed metabolic activity and viability of hepatoma cells. The EC
50
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50
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| subjects | Biomedical and Life Sciences Biomedicine Cell Biology Hepatoma Internal Medicine Laboratory Medicine Nanoparticles Pathology Permeability |
| title | Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells |
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