Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells

Biological Activity of Agaricinic Acid Nanoparticles against Human Hepatoma HepG2 Cells

A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated....

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Veröffentlicht in:Bulletin of experimental biology and medicine 2020-08, Vol.169 (4), p.508-511
Hauptverfasser: Gudkova, O. I., Demchenko, A. G., Shvets, A. V., Kuryakov, V. N., Sedyakina, N. E., Lyundup, A. V., Feldman, N. B., Gromovykh, T. I., Lutsenko, S. V.
Format: Artikel
Sprache:eng
Schlagworte:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Hepatoma
Internal Medicine
Laboratory Medicine
Nanoparticles
Pathology
Permeability
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Zusammenfassung:A stable preparation of agaricinic acid nanoparticles was obtained. The mean hydrodynamic size of nanoparticles according to photon correlation spectroscopy was 200 nm and zeta potential was -57 mV. Cytotoxic activity of agaricinic acid nanoparticles against human HepG2 hepatoma cells was evaluated. Nanoparticles with a low concentration of agaricinic acid stimulated and with high concentration — suppressed metabolic activity and viability of hepatoma cells. The EC 50 for the stimulating effect was 32.8 μg/ml, and the IC 50 =602.1 mg/ml. The preparation of agaricinic acid nanoparticles can be used in medicine as a potential antitumor agent.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-04919-1