Lower donated kidney volume is associated with increased risk of lower graft function and acute rejection at 1 year after living donor kidney—a retrospective study

Summary Kidney volume has been proven to be a surrogate marker of nephron mass and renal function. We studied 190 donor and recipient pairs undergoing living donor kidney transplantation at our institution during 9 years. Different metrics of donor kidney volume (DKV) were explored: alone or indexed...

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Veröffentlicht in:	Transplant international 2020-12, Vol.33 (12), p.1711-1722
Hauptverfasser:	Silva, Filipa, Malheiro, Jorge, Pestana, Nicole, Ribeiro, Catarina, Nunes‐Carneiro, Diogo, Mandanelo, Mariana, Tavares, Joana, Pedroso, Sofia, Almeida, Manuela, Silva‐Ramos, Miguel, Dias, Leonídeo, Martins, La Salete, Castro Henriques, António
Format:	Artikel
Sprache:	eng
Schlagworte:	acute rejection Anthropometry Antibodies Epidermal growth factor receptors Graft rejection Grafting Kidney transplantation kidney volume living donor transplantation Regression models Rejection Renal function
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Zusammenfassung:	Summary Kidney volume has been proven to be a surrogate marker of nephron mass and renal function. We studied 190 donor and recipient pairs undergoing living donor kidney transplantation at our institution during 9 years. Different metrics of donor kidney volume (DKV) were explored: alone or indexed to recipient’s anthropometry, as body surface area (BSA). DKV/BSA (min. 49.7; P33rd 77.7; P67th 95.3; max. 176 cm3/m2) was chosen given its higher correlation with eGFR at 1 year, and recipients were divided according to its tertiles (T). The eGFR at 1 year was lower in T1, when compared with T2 (P = 0.015) and T3 (P
ISSN:	0934-0874 1432-2277
DOI:	10.1111/tri.13740