Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease

DeGette and Grant discuss the case of fluoroquinolones and aortic disease. Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD). Based on this evidence, the US Food and Drug Administration issued a warn...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Archives of internal medicine (1960) 2020-12, Vol.180 (12), p.1605-1606
Hauptverfasser:	DeGette, Raphaela Lipinsky, Grant, Richard William, MPH, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aneurysm, Dissecting Anti-Bacterial Agents - adverse effects Antibiotics Aortic Diseases Cardiovascular disease Fluoroquinolones - adverse effects Humans Observational studies Studies
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	1606
container_issue	12
container_start_page	1605
container_title	Archives of internal medicine (1960)
container_volume	180
creator	DeGette, Raphaela Lipinsky Grant, Richard William MPH, MD
description	DeGette and Grant discuss the case of fluoroquinolones and aortic disease. Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD). Based on this evidence, the US Food and Drug Administration issued a warning in Dec 2018 recommending avoiding fluoroquinolone use in patients with AA/AD or who are at risk for these conditions.
doi_str_mv	10.1001/jamainternmed.2020.4191
format	Article
fullrecord	<record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2440900892</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ama_id>2770358</ama_id><sourcerecordid>2471177669</sourcerecordid><originalsourceid>FETCH-LOGICAL-a360t-8fc24deb753236561e30a2387c0d87e4517f0db9c5b4bafc76ae24673ecbb1d53</originalsourceid><addsrcrecordid>eNpdkM9KxDAQh4MoKuoLeNCAFy-7Tv40aY-y66ogeFDxWNJ2utulm2jSCnvzIXxCn8SUVUHnkoH55kfmI-SUwZgBsIulWZnGdujtCqsxBw5jyTK2RfY5U-lIMSa3f3tQe-QohCXESgGkELtkT_A00zyDffJ8XwT0b6ZrnDUtfej6ak2nGJq5pZOFaVu0cwyf7x-PC6QTE5C6ms7a3nn32jfWtc5ioMZW9NL5rinptAkYsUOyU5s24NH3e0CeZlePk5vR3f317eTybmSEgm6U1iWXFRY6EVyoRDEUYLhIdQlVqlEmTNdQFVmZFLIwdamVQS6VFlgWBasScUDON7kvw4cwdPmqCSW2rbHo-pBzKSGLl2c8omf_0KXrfbx6oDRjWiuVRUpvqNK7EDzW-YtvVsavcwb5oD__oz8f9OeD_rh58p3fF8PkZ-9HdgSON0AM-J1yrUEkqfgCJu2N0A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471177669</pqid></control><display><type>article</type><title>Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease</title><source>MEDLINE</source><source>American Medical Association Journals</source><creator>DeGette, Raphaela Lipinsky ; Grant, Richard William ; MPH, MD</creator><creatorcontrib>DeGette, Raphaela Lipinsky ; Grant, Richard William ; MPH, MD</creatorcontrib><description>DeGette and Grant discuss the case of fluoroquinolones and aortic disease. Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD). Based on this evidence, the US Food and Drug Administration issued a warning in Dec 2018 recommending avoiding fluoroquinolone use in patients with AA/AD or who are at risk for these conditions.</description><identifier>ISSN: 2168-6106</identifier><identifier>EISSN: 2168-6114</identifier><identifier>DOI: 10.1001/jamainternmed.2020.4191</identifier><identifier>PMID: 32897290</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>Aneurysm, Dissecting ; Anti-Bacterial Agents - adverse effects ; Antibiotics ; Aortic Diseases ; Cardiovascular disease ; Fluoroquinolones - adverse effects ; Humans ; Observational studies ; Studies</subject><ispartof>Archives of internal medicine (1960), 2020-12, Vol.180 (12), p.1605-1606</ispartof><rights>Copyright American Medical Association Dec 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a360t-8fc24deb753236561e30a2387c0d87e4517f0db9c5b4bafc76ae24673ecbb1d53</citedby><cites>FETCH-LOGICAL-a360t-8fc24deb753236561e30a2387c0d87e4517f0db9c5b4bafc76ae24673ecbb1d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jamanetwork.com/journals/jamainternalmedicine/articlepdf/10.1001/jamainternmed.2020.4191$$EPDF$$P50$$Gama$$H</linktopdf><linktohtml>$$Uhttps://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2020.4191$$EHTML$$P50$$Gama$$H</linktohtml><link.rule.ids>64,314,780,784,3340,27924,27925,76489,76492</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32897290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DeGette, Raphaela Lipinsky</creatorcontrib><creatorcontrib>Grant, Richard William</creatorcontrib><creatorcontrib>MPH, MD</creatorcontrib><title>Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease</title><title>Archives of internal medicine (1960)</title><addtitle>JAMA Intern Med</addtitle><description>DeGette and Grant discuss the case of fluoroquinolones and aortic disease. Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD). Based on this evidence, the US Food and Drug Administration issued a warning in Dec 2018 recommending avoiding fluoroquinolone use in patients with AA/AD or who are at risk for these conditions.</description><subject>Aneurysm, Dissecting</subject><subject>Anti-Bacterial Agents - adverse effects</subject><subject>Antibiotics</subject><subject>Aortic Diseases</subject><subject>Cardiovascular disease</subject><subject>Fluoroquinolones - adverse effects</subject><subject>Humans</subject><subject>Observational studies</subject><subject>Studies</subject><issn>2168-6106</issn><issn>2168-6114</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM9KxDAQh4MoKuoLeNCAFy-7Tv40aY-y66ogeFDxWNJ2utulm2jSCnvzIXxCn8SUVUHnkoH55kfmI-SUwZgBsIulWZnGdujtCqsxBw5jyTK2RfY5U-lIMSa3f3tQe-QohCXESgGkELtkT_A00zyDffJ8XwT0b6ZrnDUtfej6ak2nGJq5pZOFaVu0cwyf7x-PC6QTE5C6ms7a3nn32jfWtc5ioMZW9NL5rinptAkYsUOyU5s24NH3e0CeZlePk5vR3f317eTybmSEgm6U1iWXFRY6EVyoRDEUYLhIdQlVqlEmTNdQFVmZFLIwdamVQS6VFlgWBasScUDON7kvw4cwdPmqCSW2rbHo-pBzKSGLl2c8omf_0KXrfbx6oDRjWiuVRUpvqNK7EDzW-YtvVsavcwb5oD__oz8f9OeD_rh58p3fF8PkZ-9HdgSON0AM-J1yrUEkqfgCJu2N0A</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>DeGette, Raphaela Lipinsky</creator><creator>Grant, Richard William</creator><creator>MPH, MD</creator><general>American Medical Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20201201</creationdate><title>Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease</title><author>DeGette, Raphaela Lipinsky ; Grant, Richard William ; MPH, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a360t-8fc24deb753236561e30a2387c0d87e4517f0db9c5b4bafc76ae24673ecbb1d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aneurysm, Dissecting</topic><topic>Anti-Bacterial Agents - adverse effects</topic><topic>Antibiotics</topic><topic>Aortic Diseases</topic><topic>Cardiovascular disease</topic><topic>Fluoroquinolones - adverse effects</topic><topic>Humans</topic><topic>Observational studies</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DeGette, Raphaela Lipinsky</creatorcontrib><creatorcontrib>Grant, Richard William</creatorcontrib><creatorcontrib>MPH, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Archives of internal medicine (1960)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DeGette, Raphaela Lipinsky</au><au>Grant, Richard William</au><au>MPH, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease</atitle><jtitle>Archives of internal medicine (1960)</jtitle><addtitle>JAMA Intern Med</addtitle><date>2020-12-01</date><risdate>2020</risdate><volume>180</volume><issue>12</issue><spage>1605</spage><epage>1606</epage><pages>1605-1606</pages><issn>2168-6106</issn><eissn>2168-6114</eissn><abstract>DeGette and Grant discuss the case of fluoroquinolones and aortic disease. Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD). Based on this evidence, the US Food and Drug Administration issued a warning in Dec 2018 recommending avoiding fluoroquinolone use in patients with AA/AD or who are at risk for these conditions.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>32897290</pmid><doi>10.1001/jamainternmed.2020.4191</doi><tpages>2</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 2168-6106
ispartof	Archives of internal medicine (1960), 2020-12, Vol.180 (12), p.1605-1606
issn	2168-6106 2168-6114
language	eng
recordid	cdi_proquest_miscellaneous_2440900892
source	MEDLINE; American Medical Association Journals
subjects	Aneurysm, Dissecting Anti-Bacterial Agents - adverse effects Antibiotics Aortic Diseases Cardiovascular disease Fluoroquinolones - adverse effects Humans Observational studies Studies
title	Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T05%3A33%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Observational%20Study%20Design%20Challenges%E2%80%94The%20Case%20of%20Fluoroquinolones%20and%20Aortic%20Disease&rft.jtitle=Archives%20of%20internal%20medicine%20(1960)&rft.au=DeGette,%20Raphaela%20Lipinsky&rft.date=2020-12-01&rft.volume=180&rft.issue=12&rft.spage=1605&rft.epage=1606&rft.pages=1605-1606&rft.issn=2168-6106&rft.eissn=2168-6114&rft_id=info:doi/10.1001/jamainternmed.2020.4191&rft_dat=%3Cproquest_cross%3E2471177669%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2471177669&rft_id=info:pmid/32897290&rft_ama_id=2770358&rfr_iscdi=true