Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease

Observational Study Design Challenges—The Case of Fluoroquinolones and Aortic Disease

DeGette and Grant discuss the case of fluoroquinolones and aortic disease. Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD). Based on this evidence, the US Food and Drug Administration issued a warn...

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Veröffentlicht in:Archives of internal medicine (1960) 2020-12, Vol.180 (12), p.1605-1606
Hauptverfasser: DeGette, Raphaela Lipinsky, Grant, Richard William, MPH, MD
Format: Artikel
Sprache:eng
Schlagworte:
Aneurysm, Dissecting
Anti-Bacterial Agents - adverse effects
Antibiotics
Aortic Diseases
Cardiovascular disease
Fluoroquinolones - adverse effects
Humans
Observational studies
Studies
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Zusammenfassung:DeGette and Grant discuss the case of fluoroquinolones and aortic disease. Recent observational cohort studies have reported a possible association between fluoroquinolone use and aortic aneurysm and aortic dissection (AA/AD). Based on this evidence, the US Food and Drug Administration issued a warning in Dec 2018 recommending avoiding fluoroquinolone use in patients with AA/AD or who are at risk for these conditions.
ISSN:2168-6106
2168-6114
DOI:10.1001/jamainternmed.2020.4191