Dysfunction of perivascular adipose tissue in mesenteric artery is restored by aerobic exercise in high‐fat diet induced obesity

This study investigated the function of perivascular adipose tissue (PVAT) on vascular contractility within resistant arteries in high‐fat diet induced obese rats after long‐term aerobic exercise. Male Sprague‐Dawley rats were subjected to normal diet control group (N‐CTRL), normal diet exercise group (N‐EX), high‐fat diet control group (H‐CTRL), and high‐fat diet exercise group (H‐EX) (n = 8 in each group). After intervention, adipose tissues morphology was observed. Vasomotor function of mesenteric arteries with or without PVAT were assessed; mesenteric PVAT isolated from each group were transferred to chambers bath with untreated vessels (without PVAT) to evaluate the independent effect. Isolated PVAT was further pre‐treated with inhibitor of cystathionine‐γ‐lyase (CSE), a key hydrogen sulphide (H2S) enzyme. Results showed that the size of lipid droplet around mesenteric arteries from H‐EX was significantly reduced (P