Iridium-Catalyzed C‑Alkylation of Methyl Group on N‑Heteroaromatic Compounds using Alcohols

Iridium-Catalyzed C‑Alkylation of Methyl Group on N‑Heteroaromatic Compounds using Alcohols

In this study, we developed a catalytic system for the C-alkylation of a methyl group on N-heteroaromatic compounds, including pyridine, pyrimidine, pyrazine, quinoline, quinoxaline, and isoquinoline, using alcohols based on a hydrogen-borrowing process with [Cp*IrCl2]2 (Cp*: η5-pentamethylcyclopent...

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Veröffentlicht in:Organic letters 2020-09, Vol.22 (18), p.7295-7299
Hauptverfasser: Onoda, Mitsuki, Fujita, Ken-ichi
Format: Artikel
Sprache:eng
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Zusammenfassung:In this study, we developed a catalytic system for the C-alkylation of a methyl group on N-heteroaromatic compounds, including pyridine, pyrimidine, pyrazine, quinoline, quinoxaline, and isoquinoline, using alcohols based on a hydrogen-borrowing process with [Cp*IrCl2]2 (Cp*: η5-pentamethylcyclopentadienyl) combined with potassium t-butoxide and 18-crown-6-ether as the catalyst precursor.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.0c02635